| Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation. | |
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MedLine Citation:
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PMID: 16236380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of our work was to carry out a randomized clinical trial with a fast-food Mediterranean type diet rich in platelet activating factor (PAF) antagonist to investigate the effect on type 2 diabetics and healthy human subject's platelet aggregation. RESEARCH DESIGN AND METHODS: We extracted lipids from fast-food Mediterranean type foodstuffs, and tested them in vitro for their ability to inhibit or antagonize PAF towards washed rabbit platelets. We chose the foodstuffs that exerted the most potent in vitro anti-PAF activity and fed 22 healthy (group A) and 23 type 2 diabetics (group B) subjects on a diet containing the chosen foodstuffs. The 22 type 2 diabetics (group C) subjects were kept on their regular diet that was being followed before entering the study. Before and after a 4-week diet, all enrolled subjects underwent the following examinations; measurement of total cholesterol, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), triglycerides, glucose, HbA(1c), body mass index (BMI), and platelet aggregation in response to PAF, adenosine 5' diphosphate (ADP) and arachidonic acid (AA). RESULTS: The chosen diet significantly increased the EC(50) values of PAF and ADP to groups A and B (p<0.05). No statistical difference was observed on the EC(50) value of group C. No statistical differences were detected among Cholesterol, LDL-cholesterol, triglycerides, glucose, HBA(1c), BMI, and EC(50) for AA values, for any of the three groups. CONCLUSIONS: Consumption of a fast-food Mediterranean type diet rich in PAF antagonist improved platelet response of type 2 diabetics and healthy human subjects against thrombotic, inflammatory and proatherogenic factors. |
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Authors:
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Haralabos C Karantonis; Elizabeth Fragopoulou; Smaragdi Antonopoulou; John Rementzis; Costas Phenekos; Constantinos A Demopoulos |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2005-10-19 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 72 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-28 Completed Date: 2006-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 33-41 Citation Subset: IM |
Affiliation:
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National and Kapodistrian University of Athens, Faculty of Chemistry, Panepistimioupolis, 15771 Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Animals Arachidonic Acid / pharmacology Blood Platelets / drug effects, physiology Body Weight Diabetes Mellitus, Type 2 / blood* Diet Diet, Mediterranean* Energy Intake Food Analysis Humans Lipids / isolation & purification, pharmacology Middle Aged Platelet Activating Factor / pharmacology Platelet Aggregation* Platelet Aggregation Inhibitors Rabbits Reference Values Restaurants* |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Platelet Activating Factor; 0/Platelet Aggregation Inhibitors; 506-32-1/Arachidonic Acid; 58-64-0/Adenosine Diphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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