Document Detail

Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis.
MedLine Citation:
PMID:  19534614     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the effect of indigowood root (Isatis indigotica Fort.) on acute mucositis induced by radiation. DESIGN: The objective severity of mucositis, anorexia, and swallowing difficulty were measured before and after the treatment. SETTINGS: Patients with head and neck cancer receiving radiotherapy at Tian Sheng Memorial Hospital, Taiwan were recruited for this trial. SUBJECTS: Twenty (20) patients were randomized into two groups. Group 1 served as controls with only normal saline, and group 2 as the indigowood root (IR) group. INTERVENTIONS: Prophylactic application of IR consisted of gargling and then swallowing the IR preparation on the irradiated oral mucosa. OUTCOME MEASURES: Patients' characteristic distribution of gender, age, diagnosis, and mean radiation dose between the two arms were calculated by Fisher's exact test. We compared the mean of grade 1-4 mucositis, anorexia, difficulty in swallowing, and body weight change with the Mann-Whitney U test. p values less than 0.05 indicated statistical significance. RESULTS: The clinical trial showed that application of IR can reduce the severity of radiation mucositis (p = 0.01), anorexia (p = 0.002), and swallowing difficulty (p = 0.002). Although patients' resting days did not show a significant difference (p = 0.06), complete radiotherapy was done without rest for 4 of 11 patients in the IR group versus 2 of 9 in controls. Hemoglobin level between both groups showed no significant difference. Serum interleukin-6 was significantly lower in the IR group during the first, fifth, and seventh weeks. CONCLUSIONS: We confirmed that indigowood root has anti-inflammatory ability to reduce the mucosal damage caused by radiation. We postulate that indirubin may play a pharmaceutical role in improvement of radiation mucositis, anorexia, and difficulty in swallowing in our clinical trial. However, the exact mechanisms and pathways still need further analysis.
Weir Chiang You; Chang Chi Hsieh; Jia Tsz Huang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of alternative and complementary medicine (New York, N.Y.)     Volume:  15     ISSN:  1557-7708     ISO Abbreviation:  J Altern Complement Med     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508124     Medline TA:  J Altern Complement Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  771-8     Citation Subset:  IM    
Department of Radiation Oncology, Chang Bing Show Chan Hospital, Chang-Hwa, Taiwan.
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MeSH Terms
Anorexia / drug therapy,  etiology
Anti-Inflammatory Agents / therapeutic use*
Deglutition Disorders / drug therapy,  etiology
Head and Neck Neoplasms / complications,  drug therapy,  radiotherapy*
Interleukin-6 / blood
Middle Aged
Mouth Mucosa / drug effects
Mouthwashes / therapeutic use
Mucositis / drug therapy*,  etiology
Plant Preparations / therapeutic use*
Plant Roots
Radiation Injuries / drug therapy*
Radiotherapy / adverse effects
Severity of Illness Index
Statistics, Nonparametric
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Interleukin-6; 0/Mouthwashes; 0/Plant Preparations; 0/Powders

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