| Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn's disease. | |
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MedLine Citation:
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PMID: 21129005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An immunomodulatory extract (AndoSan™) based on the medicinal mushroom Agaricus blazei Murill (AbM) has shown to reduce blood cytokine levels in healthy volunteers after 12 days' ingestion, pointing to an anti-inflammatory effect. The aim was to study whether AndoSan™ had similar effects on cytokines in patients with ulcerative colitis (UC) and Crohn's disease (CD). Calprotectin, a marker for inflammatory bowel disease (IBD), was also measured. Patients with CD (n = 11) and with UC (n = 10) consumed 60 ml/day of AndoSan™. Patient blood plasma was harvested before and after 6 h LPS (1 ng/ml) stimulation ex vivo. Plasma and faecal calprotectin levels were analysed using ELISA and 17 cytokines [IL-2, IFN-γ, IL-12 (Th1), IL-4, IL-5, IL-13 (Th2), IL-7, IL-17, IL-1β, IL-6, TNF-α, IL-8, MIP-1β, MCP-1, G-CSF, GM-CSF and IL-10] by multiplex assay. After 12 days' ingestion of AndoSan™, baseline plasma cytokine levels in UC was reduced for MCP-1 (40%) and in LPS-stimulated blood for MIP-1β (78%), IL-6 (44%), IL-1β (41%), IL-8 (30%), G-CSF (29%), MCP-1 (18%) and GM-CSF (17%). There were corresponding reductions in CD: IL-2 (100%), IL-17 (55%) and IL-8 (29%) and for IL-1β (35%), MIP-1β (30%), MCP-1 (22%), IL-8 (18%), IL-17 (17%) and G-CSF (14%), respectively. Baseline concentrations for the 17 cytokines in the UC and CD patient groups were largely similar. Faecal calprotectin was reduced in the UC group. Ingestion of an AbM-based medicinal mushroom by patients with IBD resulted in interesting anti-inflammatory effects as demonstrated by declined levels of pathogenic cytokines in blood and calprotectin in faeces. |
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Authors:
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D T Førland; E Johnson; L Saetre; T Lyberg; I Lygren; G Hetland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 73 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 66-75 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Gastroenterological Surgery, Oslo University Hospital, Ullevål, Oslo, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agaricus / chemistry* Aged Cytokines / biosynthesis*, blood, immunology Feces / chemistry Female Humans Immunoassay Immunologic Factors / administration & dosage* Immunotherapy / methods* Inflammatory Bowel Diseases / blood, immunology*, therapy* Leukocyte L1 Antigen Complex / biosynthesis*, blood, immunology Male Middle Aged Statistics, Nonparametric Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Immunologic Factors; 0/Leukocyte L1 Antigen Complex |
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