| Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. | |
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MedLine Citation:
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PMID: 20307638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM OF STUDY: Andrographis paniculata has been known to possess widespread traditional application in the treatment of allergy and inflammatory diseases. In the current study, we sought to examine the effects of an extract of Andrographis paniculata leaves on inhibition of lipopolysaccharide (LPS) induced [nitric oxide (NO), prostaglandin E(2) (PGE(2)), interleukin-1beta (IL-1 beta), and interleukin-6 (IL-6)] and calcimycin (A23187) induced [leukotriene B(4) (LTB(4)), thromboxane B(2) (TXB(2)) and histamine] mediators in diverse cell based models. MATERIALS AND METHODS: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE(2), IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB(4) and TXB(2) in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells. RESULTS AND CONCLUSION: AP illustrated significant alleviation of pro-inflammatory, inflammatory, and allergic mediators. However, no inhibition was observed against histamine release. This outcome has been summed up to deduce that AP is fairly potent in attenuating the inflammation by inhibiting pro-inflammatory (NO, IL-1 beta and IL-6), inflammatory (PGE(2) and TXB(2)) and allergic (LTB(4)) mediators. |
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Authors:
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C V Chandrasekaran; Anumita Gupta; Amit Agarwal |
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Publication Detail:
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Type: Journal Article Date: 2010-03-20 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 129 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 203-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd., Bangalore, India. cvc@naturalremedy.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Andrographis*
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chemistry Animals Anti-Bacterial Agents / pharmacology Anti-Inflammatory Agents / isolation & purification, pharmacology* Calcimycin / pharmacology Cell Line Cell Line, Tumor Humans Hypersensitivity / immunology* Inflammation Mediators / isolation & purification, metabolism* Leukotriene B4 / metabolism* Lipopolysaccharides Macrophages / drug effects* Mice Plant Extracts / pharmacology* Plant Leaves Rats |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Inflammation Mediators; 0/Lipopolysaccharides; 0/Plant Extracts; 52665-69-7/Calcimycin; 71160-24-2/Leukotriene B4 |
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