| Effect of extracorporeal photopheresis on selected immunologic parameters in psoriasis vulgaris. | |
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MedLine Citation:
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PMID: 2636805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracorporeal photopheresis (ExP) was administered every other week in an outpatient setting to four patients with chronic refractory psoriasis vulgaris without arthropathy. The duration of treatment ranged from six to 13 months. Two patients received methotrexate concomitantly during the initial phase of the study. All patients demonstrated a decrease in erythema, induration, and scaling of lesional skin, accompanied by incomplete clearing of lesions such that the percentage of involvement (SI) ranged between 40 to 80 percent of baseline scores. Exacerbations of psoriasis occurred with minor provocations, and two patients who were predisposed to developing epithelial skin neoplasms as a consequence of prior treatments continued to develop tumors during the study interval. Prolonged ExP treatment was otherwise well tolerated, without evidence of toxicity on routine laboratory safety tests or changes in lymphocyte counts. All patients, however, exhibited decreased intradermal skin responses to recall antigens and a decreased capacity of peripheral lymphocytes to produce interleukin 2 (IL-2) in response to polyclonal stimuli in vitro. These observations suggest that the observed anti-inflammatory effect of alternate-week ExP on psoriasis is mediated in part to a direct inhibition of lymphokine production or release by psoralen-ultraviolet-exposed lymphocytes. |
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Authors:
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E C Vonderheid; R D Bigler; T J Rogers; M E Kadin; T D Griffin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Yale journal of biology and medicine Volume: 62 ISSN: 0044-0086 ISO Abbreviation: Yale J Biol Med Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1990-06-29 Completed Date: 1990-06-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417414 Medline TA: Yale J Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 653-64 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Hahnemann University, Philadelphia, Pennsylvania 19002. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Extracorporeal Circulation Female Humans Immunity* Immunoglobulins / analysis Interleukin-2 / biosynthesis Leukocyte Count Lymphocytes / drug effects, immunology Male Middle Aged PUVA Therapy* Psoriasis / immunology, pathology, therapy* Skin Tests |
| Grant Support | |
ID/Acronym/Agency:
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AI-23828/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Interleukin-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Yale J Biol Med Journal ID (pmc): yjbm ISSN: 0044-0086 ISSN: 1551-4056 Publisher: Yale Journal of Biology and Medicine |
Article Information Download PDF  Print publication date: Season: Nov?Dec Year: 1989 Volume: 62 Issue: 6 First Page: 653 Last Page: 664 ID: 2589147 PubMed Id: 2636805 |
| Effect of extracorporeal photopheresis on selected immunologic parameters in psoriasis vulgaris. | |
| E. C. Vonderheid | |
| R. D. Bigler | |
| T. J. Rogers | |
| M. E. Kadin | |
| T. D. Griffin | |
| Division of Dermatology, Hahnemann University, Philadelphia, Pennsylvania 19002. |
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