Document Detail

Effect of extent of myocardial damage on the behavior of myocardial zinc in albino rats.
MedLine Citation:
PMID:  7423034     Owner:  NLM     Status:  MEDLINE    
The effect of the extent of myocardial necrosis on myocardial zinc was studied in albino rats. Varying degrees of myocardial necrosis were produced by subcutaneous injection of two different doses of isoproterenol (85 mg/kg body wt and 42.5 mg/kg body wt). Myocardial necrosis was confirmed by serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum lactate dehydrogenase (SLDH), ECG, and histology. Myocardial zinc was depleted after the administration of isoproterenol. This depletion was proportional to the extent of myocardial damage. There was an attempt by the heart for re-uptake of zinc. However, this re-uptake could not be sustained in hearts with more extensive cardiac damage.
M Ahmad; Salahuddin; B M Mathew; S Kumar; T D Seth; M Z Hasan; S Q Mahdi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in myocardiology     Volume:  2     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Heart / drug effects
Isoproterenol / pharmacology
L-Lactate Dehydrogenase / blood
Myocardial Infarction / metabolism*
Myocardium / enzymology,  metabolism*,  pathology
Zinc / metabolism*
Reg. No./Substance:
7440-66-6/Zinc; 7683-59-2/Isoproterenol; EC Dehydrogenase; EC Aminotransferases; EC Transaminase

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