| Effect of extent of myocardial damage on the behavior of myocardial zinc in albino rats. | |
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MedLine Citation:
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PMID: 7423034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the extent of myocardial necrosis on myocardial zinc was studied in albino rats. Varying degrees of myocardial necrosis were produced by subcutaneous injection of two different doses of isoproterenol (85 mg/kg body wt and 42.5 mg/kg body wt). Myocardial necrosis was confirmed by serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum lactate dehydrogenase (SLDH), ECG, and histology. Myocardial zinc was depleted after the administration of isoproterenol. This depletion was proportional to the extent of myocardial damage. There was an attempt by the heart for re-uptake of zinc. However, this re-uptake could not be sustained in hearts with more extensive cardiac damage. |
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Authors:
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M Ahmad; Salahuddin; B M Mathew; S Kumar; T D Seth; M Z Hasan; S Q Mahdi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in myocardiology Volume: 2 ISSN: 0270-4056 ISO Abbreviation: Adv Myocardiol Publication Date: 1980 |
Date Detail:
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Created Date: 1980-12-16 Completed Date: 1980-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000285 Medline TA: Adv Myocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 171-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Aspartate Aminotransferases / blood Heart / drug effects Isoproterenol / pharmacology L-Lactate Dehydrogenase / blood Myocardial Infarction / metabolism* Myocardium / enzymology, metabolism*, pathology Necrosis Rats Zinc / metabolism* |
| Chemical | |
Reg. No./Substance:
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7440-66-6/Zinc; 7683-59-2/Isoproterenol; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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