Document Detail

Effect of extent of myocardial damage on the behavior of myocardial zinc in albino rats.
MedLine Citation:
PMID:  7423034     Owner:  NLM     Status:  MEDLINE    
The effect of the extent of myocardial necrosis on myocardial zinc was studied in albino rats. Varying degrees of myocardial necrosis were produced by subcutaneous injection of two different doses of isoproterenol (85 mg/kg body wt and 42.5 mg/kg body wt). Myocardial necrosis was confirmed by serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum lactate dehydrogenase (SLDH), ECG, and histology. Myocardial zinc was depleted after the administration of isoproterenol. This depletion was proportional to the extent of myocardial damage. There was an attempt by the heart for re-uptake of zinc. However, this re-uptake could not be sustained in hearts with more extensive cardiac damage.
M Ahmad; Salahuddin; B M Mathew; S Kumar; T D Seth; M Z Hasan; S Q Mahdi
Related Documents :
835594 - Serum myoglobin in myocardial infarction: the "staccato phenomenon." is acute myocardia...
19123434 - Applicability and reproducibility of biomarkers for the evaluation of anti-inflammatory...
9158164 - Serum basic fibroblast growth factor levels in patients with ischemic heart disease.
2108824 - Serum carbonic anhydrase iii and myoglobin concentrations in acute myocardial infarction.
1764824 - Painless myocardial ischemia in elderly patients compared with middle-aged patients and...
3486594 - Factors determining the activity of ischemic heart disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in myocardiology     Volume:  2     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Heart / drug effects
Isoproterenol / pharmacology
L-Lactate Dehydrogenase / blood
Myocardial Infarction / metabolism*
Myocardium / enzymology,  metabolism*,  pathology
Zinc / metabolism*
Reg. No./Substance:
7440-66-6/Zinc; 7683-59-2/Isoproterenol; EC Dehydrogenase; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in contractile function and endogenous fuel supply in rat heart upon perfusion with substrat...
Next Document:  Calcium paradox. Dependence of reperfusion-induced changes on the extracellular calcium concentratio...