| Effect of exposure to non-esterified fatty acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes: a long-term follow-up study. | |
| | |
MedLine Citation:
|
PMID: 22221293 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aim: The aim of the study was to determine whether fasting serum non-esterified fatty acid (NEFA) could be associated with long-term progressive deterioration of insulin secretion in patients with Type 2 diabetes. Methods: Seventy-seven Japanese patients with Type 2 diabetes (mean BMI 23.3 kg/m(2) ) were followed for 10 years. We measured fasting C-peptide level every 1-2 years. By using the slope of regression line between fasting C-peptide level and duration, we calculated its individual annual decline as an index of insulin secretion. During the follow-up periods of C-peptide, the patients were evaluated for fasting serum non-esterified fatty acid, LDL cholesterol, HDL cholesterol and HbA(1c) levels for the last 8 years. We excluded patients who had renal dysfunction or anti-insulin antibodies from among the insulin-treated patients. Association between the individual annual decline of fasting C-peptide level and related factors were evaluated. Results: The mean individual annual decline of fasting serum C-peptide level was -0.013 ± 0.027 nmol/l/year. Fasting serum non-esterified fatty acid level had no significant difference between the first and the last 2 years of the 8-year observation period of non-esterified fatty acid. Using multiple regression analysis, mean fasting serum non-esterified fatty acid level was associated with the individual annual decline of fasting serum C-peptide level (standardized regression coefficient -0.358, P = 0.0056), although other related factors, including HbA(1c) level, were not associated. Conclusions: Mean fasting serum non-esterified fatty acid level during an 8-year observation was independently associated with long-term progressive deterioration of insulin secretion in Japanese patients with Type 2 diabetes. © 2011 The Authors. Diabetic Medicine© 2011 Diabetes UK. |
| | |
Authors:
|
S Morita; Y Shimajiri; S Sakagashira; M Furuta; T Sanke |
Related Documents
:
|
2422103 - Twenty-four hour blood glucose profiles during insulin and insulin plus aprotinin subcu... 20482243 - Ease of use and patient preference injection simulation study comparing two prefilled i... 18423813 - Kidney function and risk factors for left ventricular hypertrophy in untreated uncompli... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
|
Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. |
Affiliation:
|
Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Social and Medical Vulnerability Factors of Emergency Department Frequent Users in a Universal Healt...
Next Document: MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children.