| Effect of exposure to hyperbaric oxygen on diabetes-induced cataracts in mice. | |
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MedLine Citation:
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PMID: 21801331 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The growth-associated increase in the blood glucose level of animals with type 2 diabetes is inhibited by moderate hyperbaric exposure at 1.25 atmospheres absolute with 36% oxygen presumably due to an increase in oxidative metabolism. However, there are no data available on the effect of moderate hyperbaric oxygen on diabetes-induced cataracts. Methods: Four-week-old mice with type 2 diabetes and cataracts were exposed to 1.25 atmospheres absolute with 36% oxygen, 6 hours daily for 12 weeks, followed by normal conditions at 1 atmosphere absolute with 21% oxygen for 16 weeks (cataract + hyperbaric group). Levels of blood glucose and derivatives of reactive oxygen metabolites (dROMs), used as an index of oxidative stress, and turbidities of the lenses from these mice at 4, 8, 12, 16, and 32 weeks of age were compared with those of control (control group) and diabetic (cataract group) mice not exposed to hyperbaric oxygen. Results: The non-fasting and fasting blood glucose levels were lower in the cataract + hyperbaric group at 12, 16, and 32 weeks than in the age-matched cataract group. The levels of dROMs were lower in the cataract + hyperbaric group at 16 and 32 weeks than in the age-matched cataract group. The turbidities of the peripheral and central regions of the lenses were lower in the cataract + hyperbaric group at 12, 16, and 32 weeks than in the age-matched cataract group. Conclusions: Hyperbaric exposure at 1.25 ATA with 36% oxygen delays cataract development and progression in mice with type 2 diabetes. |
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Authors:
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Fumiko Nagatomo; Roland R Roy; Hisahide Takahashi; V Reggie Edgerton; Akihiko Ishihara |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-1 |
Journal Detail:
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Title: Journal of diabetes Volume: - ISSN: 1753-0407 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan Brain Research Institute, University of California, Los Angeles, CA, USA Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Japan Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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