| Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring mice. | |
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MedLine Citation:
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PMID: 17151444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isoflavone (IF), a type of phytoestrogen, has multiple beneficial effects, but too much phytoestrogen can have adverse effects on offspring. To examine whether chronic exposure to high IF has adverse effects on reproductive development, mice offspring were exposed to IF through dietary administration to dams during pregnancy and lactation and to the offspring directly after weaning until sacrifice. In male offspring, there was no difference between the IF group and controls; however, in female offspring in the IF group, remarkably earlier puberty and induction of multioocyte follicles on postnatal day (PND) 21 were observed. Gene expression levels of estrogen receptor beta decreased in the ovary and vagina on PND 21. These results suggest that chronic exposure to higher than normal levels of IF induces alterations in the reproductive development of female mice through an estrogenic effect. |
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Authors:
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Kyoka Takashima-Sasaki; Masatoshi Komiyama; Tetsuya Adachi; Kenichi Sakurai; Hideo Kato; Taisen Iguchi; Chisato Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 70 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 2874-82 Citation Subset: IM |
Affiliation:
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Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Body Weight / drug effects DNA Primers Diet* Feeding Behavior / drug effects Female Genitalia, Female / drug effects, growth & development Genitalia, Male / drug effects, growth & development Isoflavones / administration & dosage, pharmacology* Male Maternal Exposure* Mice Mice, Inbred C57BL Pregnancy Reverse Transcriptase Polymerase Chain Reaction Sexual Maturation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Isoflavones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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