Document Detail

Effect of experimental hyposalivation on the induction of dental caries in rats infected with Streptococcus mutans.
MedLine Citation:
PMID:  2149676     Owner:  NLM     Status:  MEDLINE    
The effects of hyposalivation on the induction of dental caries were examined in specific pathogen-free Sprague-Dawley rats infected with Streptococcus mutans MT8148R and fed the caries-inducing diet 2000. Hyposalivation was induced by either irradiation or surgical removal of salivary glands in 30-day-old rats. After either procedure, severe dental caries was induced in the rats when examined at 84 days of age, and a statistically significant correlation was found between caries scores and flow rates of saliva. However, the recovery of strain MT8148R from hyposalivated rats was not always high, and it is possible that microorganisms other than the inoculated S. mutans strain MT8148R may have played a role in promoting dental caries.
T Ooshima; T Hashida; H Fuchihata; T Fujiwara; T Yoshida; A Izumitani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Caries research     Volume:  24     ISSN:  0008-6568     ISO Abbreviation:  Caries Res.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  446-51     Citation Subset:  D; IM    
Department of Pedodontics, Osaka University, Faculty of Dentistry, Japan.
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MeSH Terms
Dental Caries / etiology*,  microbiology
Radiation Dosage
Rats, Inbred Strains
Saliva / secretion
Salivary Glands / physiopathology,  radiation effects,  surgery
Secretory Rate / radiation effects
Specific Pathogen-Free Organisms
Streptococcus mutans / physiology*
Xerostomia / complications*,  physiopathology

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