Document Detail

Effect of exogenous urotensin-II on vascular tone in skin microcirculation of patients with essential hypertension.
MedLine Citation:
PMID:  16182109     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Plasma levels of urotensin-II (U-II) have been found to be elevated in patients with essential hypertension. However, the consequence of activation of the U-II system have not been previously determined in these patients. We therefore compared the effect of exogenous U-II administration on vascular tone in hypertensive patients (n = 13) and normotensive subjects (n = 14). METHODS: The effect of U-II on vascular tone was determined in the forearm skin microcirculation using iontophoresis to administer the drug and laser Doppler velocimetry to measure microvascular response. RESULTS: The U-II administration was associated with a dose-dependent vasodilator response from baseline in normotensive subjects (U-II 1 x 10(-12) mol/L, 609 +/- 164; U-II 1 x 10(-9) mol/L, 839 +/- 216; U-II, 1 x 10(-7) mol/L, 1249 +/- 228 arbitrary flux units; P < .0005). A dose-dependent vasoconstrictor response was observed in hypertensive patients compared to baseline (U-II 1 x 10(-12) mol/L, 60 +/- 212; U-II 1 x 10(-9) mol/L, -288 +/- 172; U-II, 1 x 10(-7) mol/L, -607 +/- 165 arbitrary flux units; P < .005). Differences in flow between the two groups were significant at the 1 x 10(-9) mol/L and 1 x 10(-7) mol/L dose levels (P < .001). In contrast, there was no significant difference in flux between baseline and U-II in either group (or between groups) when the opposite polarity was applied. CONCLUSIONS: The demonstration of opposing effects of exogenous U-II in patients with hypertension and normal subjects suggests that U-II may be contributory to the increased vascular tone of these patients.
Brigitte Sondermeijer; Andrew Kompa; Paul Komesaroff; Henry Krum
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  18     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-12-21     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1195-9     Citation Subset:  IM    
Department of Medicine, Monash University, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia.
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MeSH Terms
Acetylcholine / administration & dosage,  pharmacology
Administration, Cutaneous
Blood Flow Velocity / drug effects
Forearm / blood supply
Hypertension / physiopathology*
Iontophoresis / methods
Microcirculation / drug effects
Middle Aged
Nitroprusside / administration & dosage,  pharmacology
Skin / blood supply*
Urotensins / administration & dosage,  pharmacology*
Vasodilator Agents / administration & dosage,  pharmacology
Reg. No./Substance:
0/Urotensins; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 9047-55-6/urotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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