Document Detail

Effect of exogenous tetragastrin on gastric myoelectrical activity in humans.
MedLine Citation:
PMID:  10733159     Owner:  NLM     Status:  MEDLINE    
It is known that cutaneous electrogastrography (EGG) undergoes a change after food ingestion, showing increases in frequency and amplitude compared with preprandial values, but the factors regulating such changes remain to be elucidated. Paying special attention to gastrin, one of gastrointestinal peptides released after food ingestion, we administered tetragastrin in an exogenous manner and evaluated its effects on EGG in the present study. In healthy subjects, the intramuscular injection of tetragastrin significantly increased EGG frequency dose-dependently, but caused no significant change in amplitude. These results suggest that the increase in endogenous gastrin release is one of the mechanisms which underlies the increase in EGG frequency after food ingestion.
H Takayasu; S Harasawa; T Miwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  24     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-06-12     Completed Date:  2000-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Division of Gastroenterology II, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
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MeSH Terms
Gastrointestinal Agents / administration & dosage,  pharmacology*
Stomach / drug effects*,  physiology
Tetragastrin / administration & dosage,  pharmacology*
Time Factors
Reg. No./Substance:
0/Gastrointestinal Agents; 1947-37-1/Tetragastrin

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