Document Detail

Effect of exogenous surfactant on eustachian tube function in the rat.
MedLine Citation:
PMID:  2817244     Owner:  NLM     Status:  MEDLINE    
Three solutions, surfactant prepared from pig lungs, a mixture of synthetic phospholipids, and saline solution, were instilled into the middle ears of rats. The middle ear pressure necessary to force the eustachian tube open was studied. Ten minutes after instillation of pulmonary surfactant there was a 0.58 +/- 0.10 kPa decrease in the pressure opening level (P less than .001). The reduction persisted throughout the 50-minute experiment. There was also a reduction 0.17 +/- 0.16 kPa in the pressure opening level (P less than .01) after the administration of the synthetic phospholipid mixture. This reduction was significantly less than the reduction produced by the pulmonary surfactant. No decrease in the pressure opening level was seen after the instillation of saline solution into the middle ear cavity. The fact that surfactants are demonstrable in the middle ear and eustachian tube, coupled with these findings of an effect on the tubal opening, suggests a physiologic role for surface tension-lowering substances in tubal function.
P White
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  10     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1989-11-28     Completed Date:  1989-11-28     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
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MeSH Terms
Eustachian Tube / drug effects*,  physiology
Pulmonary Surfactants / administration & dosage,  pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Pulmonary Surfactants

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