| Effect of exogenous somatostatin infusion on gastrointestinal blood flow and hormones in the conscious dog. | |
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MedLine Citation:
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PMID: 2856879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effects of intravenous somatostatin infusion on gastrointestinal blood flow and hormone release in conscious dogs. Gastric, duodenal, jejunal, and pancreatic blood flows, quantitated using radioactive microspheres, were significantly decreased during somatostatin infusion (200 and 500 ng/kg min), resulting in an overall 30% reduction in summed portal blood flow. Fasting blood levels of glucose fell an average of 10 mg/dl. Immunoreactive insulin, gastrin, glucagon, and pancreatic polypeptide were all profoundly suppressed by somatostatin infusion. Our studies provide one possible explanation for somatostatin's apparent effectiveness in the control of upper gastrointestinal hemorrhage. |
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Authors:
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B A Price; B M Jaffe; M J Zinner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 88 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-01-22 Completed Date: 1985-01-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 80-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Digestive System / blood supply*, drug effects Dogs Gastrointestinal Hormones / blood* Hemodynamics / drug effects Microspheres Pancreatic Hormones / blood* Regional Blood Flow / drug effects Somatostatin / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Gastrointestinal Hormones; 0/Pancreatic Hormones; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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