Document Detail


Effect of exhaustive exercise stress on the cytokine response.
MedLine Citation:
PMID:  9139173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen athletes were investigated 24 h before, 1 h after, and 20 h after an exhaustive exercise stress test (mean duration 68 min). Testing for cytokines was done in serum, urine, and the supernatants of whole blood cell cultures, which were stimulated with lipopolysaccharide (LPS), concanavalin A (Con A), or phythaemagglutinin (PHA). Elevated levels of interleukin 6 (IL-6) and soluble IL-2 receptor (sIL-2R) were found 1 h after the run in both serum and urine samples. TNF-alpha in serum was also increased, whereas IL-2 in urine was decreased after the exercise. All other testings in serum and urine (including IFN-gamma) gave borderline or negative results. In cell cultures, the LPS-induced release of the inflammatory cytokines TNF-alpha, IL-1, and IL-6 was suppressed 1 h after exercise. Also, the Con-A-induced and LPS-induced release of IFN-gamma, and the PHA-induced release of IL-2 were suppressed 1 h after exercise. In contrast, Con-A-induced release of IL-2 was mildly increased after the run. We conclude that exercise of the intensity and duration described here causes an activation of the immune system, which is immediately counter-regulated. Twenty hours after the exercise, most of the observed changes were back to pre-exercise levels, indicating only a short duration for this suppressive counter-regulation.
Authors:
C Weinstock; D König; R Harnischmacher; J Keul; A Berg; H Northoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  29     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  345-54     Citation Subset:  IM; S    
Affiliation:
Department of Transfusion Medicine, Eberhard-Karls-Universität, Tübingen, GERMANY. weinstock@unituebingen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling / physiology
Blood Cells / immunology
Cells, Cultured
Concanavalin A / pharmacology
Cytokines / blood,  immunology*,  urine
Exercise / physiology*
Follow-Up Studies
Homeostasis
Humans
Interferon-gamma / blood,  immunology,  urine
Interleukin-1 / blood,  immunology,  urine
Interleukin-2 / blood,  immunology,  urine
Interleukin-6 / blood,  immunology,  urine
Lipopolysaccharides / pharmacology
Male
Phytohemagglutinins / pharmacology
Receptors, Interleukin-2 / analysis,  blood,  immunology
Running / physiology
Stress, Physiological / immunology*
Swimming / physiology
Tumor Necrosis Factor-alpha / analysis,  immunology,  urine
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Lipopolysaccharides; 0/Phytohemagglutinins; 0/Receptors, Interleukin-2; 0/Tumor Necrosis Factor-alpha; 11028-71-0/Concanavalin A; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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