Document Detail

Effect of exercise training on resistance arteries in rats with chronic NOS inhibition.
MedLine Citation:
PMID:  19498093     Owner:  NLM     Status:  MEDLINE    
Regular exercise has blood pressure-lowering effects, as shown in different types of experimental hypertension models in rats, including the nitric oxide synthase (NOS) inhibition model. We aimed to investigate possible mechanisms implicated in the exercise effect by evaluating the vasoreactivity of resistance arteries. Exercise effects on agonist-induced vasodilatory responses and flow-mediated dilation were evaluated in vessel segments of the rat chronic NOS inhibition model. Normotensive and hypertensive rats were subjected to swimming exercise (1 h/day, 5 days/wk, 6 wk), while rats in other sedentary and hypertensive groups did not. Hypertension was induced by oral administration of the nonselective NOS inhibitor l-NAME (25 mg/kg day) for 6 wk. Systolic blood pressure, as measured by the tail-cuff method, was significantly decreased by the training protocol in exercising hypertensive rats. The vasoreactivity of resistance arteries was evaluated by both wire and pressure myography studies. An impaired nitric oxide-mediated relaxation pathway in untrained hypertensive rats led to decreased relaxation responses in vessels with intact endothelium. Exercise training significantly improved the responses to acetylcholine and flow-mediated dilation in exercise-trained hypertensive rats in parallel with a decrease in blood pressure. On the other hand contraction (norepinephrine and KCl) and relaxation (sodium nitroprusside) responses of vascular smooth muscle were not different between the groups. Vascular endothelial NOS protein expression was found to be increased in both exercising groups. In conclusion, these results revealed evidence of an increased role of the nitric oxide-dependent relaxation pathway in exercising hypertensive rats.
Oktay Kuru; Umit Kemal Sentürk; Günnur Koçer; Sadi Ozdem; Oğuz K Başkurt; Arzu Cetin; Akin Yeşilkaya; Filiz Gündüz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-04
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-10-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  896-902     Citation Subset:  IM    
School of Health Sciences, Mugla University, Mugla, Turkey.
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MeSH Terms
Acetylcholine / pharmacology
Arteries / drug effects*,  physiology*
Blood Pressure / drug effects,  physiology
Body Weight / physiology
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology*
Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism
Isoenzymes / antagonists & inhibitors,  metabolism
Muscle Relaxation / drug effects,  physiology
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors*
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Physical Conditioning, Animal / physiology*
Rats, Wistar
Vascular Resistance / drug effects*,  physiology*
Vasoconstrictor Agents / pharmacology
Vasodilation / drug effects,  physiology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Isoenzymes; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; EC Oxide Synthase; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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