| Effect of exercise training in patients with heart failure: a pilot study on autonomic balance assessed by heart rate variability. | |
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MedLine Citation:
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PMID: 15187821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Heart rate variability (HRV) is decreased in patients with congestive heart failure (CHF) and is a prognostic marker in this disease. Exercise training is now regarded as an important part of the treatment of patients with CHF, but the effect on HRV and the association between this effect and the effect on neurohormones are not well assessed. METHODS: Heart rate recording was performed in 12 patients with CHF (mean age 67+/-8 years) with CHF NYHA functional class III, before and after 12 weeks of exercise training. The association with exercise capacity and serum levels of atrial natriuretic peptide was assessed. We also evaluated the correlation between HRV and survival at follow-up 87 months later. RESULTS: At baseline there was a significant correlation between mean heart rate and work performed during max cycle test (r=0.650, P=0.022) and the HRV parameter standard deviation normal to normal (SDNN) (r=0.678, P=0.015). After exercise training there was a significant increase in work performed (30.3+/-14.2 versus 38.1+/-14.1 kJ), 6-min walk test (502+/-88 versus 552+/-59 m, P=0.006) and SDNN (117.3+/-40.7 versus 128.6+/-42.3 ms, P=0.028). At 87 months of follow-up, there was a borderline significant difference between survivors and non-survivors. Only the survivors had a significant increase in SDNN after exercise training. CONCLUSION: This pilot study demonstrates an improvement with regard to parameters for HRV after exercise training in patients with CHF. The study suggests that the positive effect of exercise training in patients with CHF involves an attenuation of the reduced HRV response, and that this improvement might have prognostic significance. |
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Authors:
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Alf Inge Larsen; Knut Gjesdal; Christian Hall; Pål Aukrust; Torbjørn Aarsland; Kenneth Dickstein |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 11 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-06-09 Completed Date: 2004-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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University of Bergen, Cardiology Division, Central Hospital in Rogaland, Stavanger, Norway. al-i-lar@online.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Natriuretic Factor / blood Autonomic Nervous System / physiopathology Exercise / physiology* Heart Failure / blood, physiopathology*, rehabilitation* Heart Rate / physiology* Humans Male Middle Aged Pilot Projects Protein Precursors / blood Rest / physiology |
| Chemical | |
Reg. No./Substance:
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0/N-terminal proatrial natriuretic peptide; 0/Protein Precursors; 85637-73-6/Atrial Natriuretic Factor |
| Comments/Corrections | |
Comment In:
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Eur J Cardiovasc Prev Rehabil. 2004 Apr;11(2):168-70
[PMID:
15187822
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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