Document Detail


Effect of exercise training on ethanol-induced oxidative damage in aged rats.
MedLine Citation:
PMID:  19185211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known that lipid peroxidation increases with age, and alcohol drinking further exacerbates this damage. The present study determined the effect of regular exercise training on alcohol-induced oxidative damage and antioxidant status in the liver of aged animals. The age-matched Wistar albino rats (3 months young, n=24; 18 months old, n=24) were evenly divided into four groups: control (C), exercise trained (Ex), ethanol drinking (Et), and exercise plus ethanol drinking (Ex+Et). With ethanol drinking, hepatic malondialdehyde (MDA) level was significantly elevated above control (P<.001), whereas glutathione (GSH) and ascorbic acid (vitamin C) contents were significantly decreased below control. These changes were found to be greater in the aged rats than those of the young rats. For both age groups, exercise training significantly reversed the increase in MDA and decreases in GSH and ascorbic acid induced by ethanol drinking. The present study showed that ethanol-induced deterioration in lipid peroxidation and reduction in antioxidant status in the liver were exacerbated with age. Here, we found that exercise training significantly reversed the adverse conditions that were caused by ethanol in aged rats.
Authors:
K Mallikarjuna; K Nishanth; Chien-Wen Hou; Chia-Hua Kuo; K Sathyavelu Reddy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  43     ISSN:  1873-6823     ISO Abbreviation:  Alcohol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Affiliation:
Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Alcohol Drinking / metabolism,  psychology
Animals
Antioxidants / metabolism
Ascorbic Acid / metabolism
Central Nervous System Depressants / toxicity*
Ethanol / toxicity*
Glutathione / metabolism
Lipid Peroxidation / drug effects
Liver / drug effects,  metabolism
Male
Malondialdehyde / metabolism
Oxidative Stress / drug effects*
Physical Conditioning, Animal / physiology*
Physical Endurance / physiology
Rats
Rats, Wistar
Uric Acid / metabolism
Xanthine Oxidase / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Central Nervous System Depressants; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 64-17-5/Ethanol; 69-93-2/Uric Acid; 70-18-8/Glutathione; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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