Document Detail


Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: A randomized clinical trial.
MedLine Citation:
PMID:  23165609     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We determined the effects of 2 years of exercise training and soy isoflavone supplementation on bone mass and lipids in postmenopausal women provided with calcium and vitamin D. Women were randomized to 4 groups: Exercise training (Ex); Isoflavone supplementation (Iso; 165 mg·d(-1) [105 mg·d(-1) aglycone equivalent]); combined Ex and Iso (ExIso); and placebo (control). Exercise included resistance training (2 d·wk(-1) ) and walking (4 d·wk(-1) ). Our primary outcomes were lumbar spine and hip bone mineral density (BMD). Secondary outcomes included hip geometry, tibia and radius speed of sound (SOS), dynamic balance (6 m backwards tandem walking), blood lipids, mammography, and endometrial thickness. 351 women (Ex=86, Iso=90, ExIso=87, control=88) were randomized with 298 analyzed at 2 years (Ex=77, Iso=76, ExIso=72, control=73). There was a significant interaction for total hip BMD (p<0.001) such that ExIso had a greater rate of decrease (absolute change [95% CI] = -0.018 [-0.024, -0.012] g/cm(2) ) than either Ex or Iso groups alone (-0.005 [-0.01, 0.001] and -0.005 [-0.009, 0.001] g/cm(2) , respectively). There were no differences between groups for changes in lumbar spine BMD and minimal significant changes in hip geometric properties and bone SOS. Exercise groups improved dynamic balance as measured by a decrease in backwards tandem walking time over 6 m (p=0.017). Isoflavone groups decreased low density lipoproteins (Iso and ExIso: -0.20 [-0.37, -0.02] mmol/L; ExIso: -0.23 [-0.40, -0.06] mmol/L; p=0.003) compared to non-isoflavone groups (Ex: 0.01 [-0.16, 0.18] mmol/L; control: -0.09 [-0.27, 0.08] mmol/L) and had lower adverse reports of menopausal symptoms (14% vs. 33%; p=0.01) compared to non-isoflavone groups. Isoflavone supplementation did not increase endometrial thickness or abnormal mammograms. We conclude exercise training and isoflavone supplementation maintain hip BMD compared to control, but these two interventions interfere with each other when combined. Isoflavone supplementation decreased LDL and adverse events related to menopausal symptoms. NCT00204425 (Clinicaltrials.gov). © 2012 American Society for Bone and Mineral Research.
Authors:
Philip D Chilibeck; Hassanali Vatanparast; Roger Pierson; Allison Case; Olufemi Olatunbosun; Susan J Whiting; Thomas J Beck; Punam Pahwa; H Jay Biem
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  -     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Bone and Mineral Research.
Affiliation:
College of Kinesiology, University of Saskatchewan, Saskatoon SK, Canada. phil.chilibeck@usask.ca.
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