| Effect of exercise training on chromogranin A and relationship to N-ANP and inflammatory cytokines in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 17586073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise training improves functional parameters in patients with congestive heart failure (CHF). The aim of this study was to establish whether exercise training influence the elevated CgA levels in CHF patients. Plasma CgA was determined at baseline and at peak exercise before and after 12 weeks of training in 25 men (mean age 67+/-8 years) with CHF (NYHA functional class II and III). Plasma Chromogranin A (CgA) was significantly elevated in CHF, however without change after the 12 week exercise period. A positive correlation was obtained for CgA versus N-ANP and CgA versus TNFalpha for the patients with poor survival, indicating that in these patients the elevated plasma CgA was more closely connected to the myocardial release of natriuretic peptides and the inflammatory response than to activation of the sympathoadrenergic system. |
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Authors:
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Alf Inge Larsen; Karen B Helle; Monika Christensen; Jan T Kvaløy; Torbjørn Aarsland; Kenneth Dickstein |
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Publication Detail:
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Type: Letter Date: 2007-06-21 |
Journal Detail:
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Title: International journal of cardiology Volume: 127 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-27 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 117-20 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Natriuretic Factor / blood* Chromogranin A / blood* Chronic Disease Cytokines / blood* Exercise Therapy* Heart Failure / blood*, physiopathology, therapy* Humans Male Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A; 0/Cytokines; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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