Document Detail

Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure.
MedLine Citation:
PMID:  19524243     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure.
METHODS: A total of 267 women [mean body mass index (BMI)=32.0+/-5.7kg/m(2) and mean age=57.3+/-6.6 years] underwent a 6-month exercise intervention program. Exercise training was performed 3-4 times per week at a targeted heart rate corresponding to 50% of the maximal oxygen consumption.
RESULTS: Compared to baseline values, mean change in relative VO(2) max (the primary endpoint) was of 1.18+/-2.25mL/minkg (p<0.0001), mean weight loss was of 1.4+/-3.3kg (p<0.0001), mean reduction in waist circumference was of 2.4+/-6.9cm (p<0.0001) and systolic blood pressure did not change significantly (-1.2+/-13.0mmHg, NS). No changes were observed in markers of the lipoprotein-lipid profile. No changes were observed for plasma levels of C-reactive protein, interleukin-6, tumor-necrosis factor-alpha and adiponectin. Changes in VO(2) max were negatively associated with changes in body weight (r=-0.26, p<0.0001) and waist circumference (r=-0.16, p=0.01), but not with changes in cardiometabolic risk markers.
CONCLUSION: Although exercise training significantly increased cardiorespiratory fitness in these sedentary, but metabolically healthy obese/overweight women with a moderately elevated systolic blood pressure, no significant improvements were observed in their cardiometabolic risk profile.
Benoit J Arsenault; Mélanie Côté; Amélie Cartier; Isabelle Lemieux; Jean-Pierre Després; Robert Ross; Conrad P Earnest; Steven N Blair; Timothy S Church
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-05-21
Journal Detail:
Title:  Atherosclerosis     Volume:  207     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-01-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  530-3     Citation Subset:  IM    
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
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MeSH Terms
Adiponectin / blood
Biological Markers / blood
Blood Pressure*
Body Mass Index
C-Reactive Protein / metabolism
Cardiovascular Diseases / etiology,  metabolism,  physiopathology,  prevention & control*
Exercise Therapy*
Inflammation Mediators / blood
Interleukin-6 / blood
Lipids / blood
Lipoproteins / blood
Middle Aged
Obesity / complications,  metabolism,  physiopathology,  therapy*
Overweight / complications,  metabolism,  physiopathology,  therapy*
Oxygen Consumption
Physical Fitness
Prospective Studies
Risk Factors
Sedentary Lifestyle*
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha / blood
Waist Circumference
Weight Loss
Grant Support
R01 HL066262-01/HL/NHLBI NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/Inflammation Mediators; 0/Interleukin-6; 0/Lipids; 0/Lipoproteins; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

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