Document Detail


Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats.
MedLine Citation:
PMID:  17475680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise training results in cardiovascular and metabolic adaptations that may be beneficial in menopausal women by reducing blood pressure, insulin resistance, and cholesterol level. The adaptation of the cardiac hormonal systems oxytocin (OT), natriuretic peptides (NPs), and nitric oxide synthase (NOS) in response to exercise training was investigated in intact and ovariectomized (OVX) rats. Ovariectomy significantly augmented body weight (BW), left ventricle (LV) mass, and intra-abdominal fat pad weight and decreased the expression of oxytocin receptor (OTR), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanylyl cyclase-A (GC-A), in the right atrium (RA) and LV, indicating estrogenic control of these genes. These effects of ovariectomy were counteracted by 8-wk-long exercise training which decreased fat pad weight (33.4 +/- 2.3 to 23.4 +/- 3.1 g, n = 8, P < 0.05), plasma free fatty acids (0.124 +/- 0.033 to 0.057 +/- 0.010 mM, n = 8, P < 0.01), and plasma triacylglycerol (0.978 +/- 0.174 to 0.588 +/- 0.115 mM, n = 8, P < 0.05). Chronic exercise tended to decrease BW and stimulated ANP (4- to 5-fold) and OTR gene expression in the LV and RA and BNP and inducible NOS (iNOS) mRNA in the LV. In sham-operated rats, exercise augmented ANP expression in the RA, downregulated GC-A mRNA in the LV and RA, but increased its expression threefold in the RA of OVX animals. Endothelial NOS and iNOS expression was enhanced in the left atrium of sham-operated rats. Altogether, these data indicate that in OVX animals, chronic exercise significantly enhances cardiac OT, NPs, and NOS, thus implicating all three hormonal systems in the beneficial effects of exercise training.
Authors:
Jolanta Gutkowska; Amélie Paquette; Donghao Wang; Jean-Marc Lavoie; Marek Jankowski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-02
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R267-75     Citation Subset:  IM    
Affiliation:
Laboratory of Cardiovascular Biochemistry, CHUM-Hôtel-Dieu Centre de Recherche, 3850 Rue Saint-Urbain, Pavillon Masson, Montréal, Québec, Canada. jolanta.gutkowska@umontreal.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / metabolism
Blotting, Western
Female
Heart / physiology*
Hypothalamus / metabolism
Myocardium / enzymology,  metabolism*
Natriuretic Peptides / physiology*
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / metabolism
Ovariectomy*
Oxytocin / metabolism*
Physical Conditioning, Animal / physiology*
Physical Endurance / physiology
Rats
Rats, Sprague-Dawley
Receptors, Oxytocin / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Natriuretic Peptides; 0/Receptors, Oxytocin; 10102-43-9/Nitric Oxide; 50-56-6/Oxytocin; 85637-73-6/Atrial Natriuretic Factor; EC 1.14.13.39/Nitric Oxide Synthase Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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