| Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure. | |
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MedLine Citation:
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PMID: 17517350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. METHODS AND RESULTS: After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. CONCLUSIONS: Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload. |
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Authors:
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Maaike G J Gademan; Cees A Swenne; Harriette F Verwey; Arnoud van der Laarse; Arie C Maan; Hedde van de Vooren; Johannes van Pelt; Henk J van Exel; Caroline M H B Lucas; Ger V J Cleuren; Soeresh Somer; Martin J Schalij; Ernst E van der Wall |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of cardiac failure Volume: 13 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-22 Completed Date: 2007-08-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 294-303 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arginine
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metabolism Autonomic Nervous System Diseases / etiology*, physiopathology, therapy* Baroreflex Catecholamines / metabolism Chronic Disease Endothelins / metabolism Exercise Therapy* Heart Failure / complications*, metabolism, physiopathology, therapy* Heart Rate Humans Natriuretic Peptide, Brain / metabolism Neurotransmitter Agents / metabolism* Renin-Angiotensin System Treatment Outcome Vasopressins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Endothelins; 0/Neurotransmitter Agents; 11000-17-2/Vasopressins; 114471-18-0/Natriuretic Peptide, Brain; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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