Document Detail

Effect of exercise training on ANP receptors.
MedLine Citation:
PMID:  11913714     Owner:  NLM     Status:  MEDLINE    
To clarify whether exercise-training affects ANP function, we trained male Wistar rats by treadmill running for nine weeks and measured ANP receptor number and affinity in the kidney, lung and adrenal. We also measured guanylate cyclase activity, by which second messenger cGMP accumulates. The number of adrenal ANP receptor significantly increased after exercise-training. There was no significant difference of affinity for all the organs examined between the training group and the control group. Guanylate cyclase activity tended to decrease in the kidney in the training group. A significant difference was found when the samples were stimulated by C-type natriuretic peptide (CNP). There was no significant difference in guanylate cyclase activity in the lung and adrenal. These findings are consistent with the exercise-induced hypervolemia, but not with the anti-hypertensive role of exercise-training.
K Suda; H Hagiwara; Y Kotani; K Kato; M Sasaki; T Izawa; T Komabayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  108     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  2000  
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-35     Citation Subset:  IM    
Department of Human System Science, Tokyo Institute of Technology, Japan.
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MeSH Terms
Adrenal Glands / metabolism
Atrial Natriuretic Factor / pharmacology
Cyclic GMP / metabolism
Guanylate Cyclase / metabolism
Kidney / metabolism
Lung / metabolism
Natriuretic Peptide, C-Type / pharmacology
Physical Conditioning, Animal / physiology
Rats, Wistar
Receptors, Atrial Natriuretic Factor / metabolism*
Second Messenger Systems
Reg. No./Substance:
127869-51-6/Natriuretic Peptide, C-Type; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC Cyclase; EC, Atrial Natriuretic Factor

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