| Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. | |
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MedLine Citation:
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PMID: 15087413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective of this study was to examine the effects of a 12-month moderate-intensity exercise intervention on serum estrogens. We randomly assigned 173 sedentary, overweight (body mass index > 24.0 kg/m(2), body fat > 33%), postmenopausal women, ages 50-75 years, not using hormone therapy, living in the Seattle, Washington, area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 days/week moderate intensity sports/recreational exercise). A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/week of exercise. After 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and 8.2%, respectively, versus no change or increased concentrations in controls (P = 0.03, 0.07, and 0.02, respectively). At 12 months, the direction of effect remained the same, although the differences were no longer statistically significant. The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by >/==" BORDER="0">2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens. |
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Authors:
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Anne McTiernan; Shelley S Tworoger; Cornelia M Ulrich; Yutaka Yasui; Melinda L Irwin; Kumar B Rajan; Bess Sorensen; Rebecca E Rudolph; Deborah Bowen; Frank Z Stanczyk; John D Potter; Robert S Schwartz |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 64 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-16 Completed Date: 2004-06-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 2923-8 Citation Subset: IM |
Affiliation:
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Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Estrogens / blood* Exercise / physiology* Female Humans Middle Aged Obesity / blood Patient Compliance Postmenopause / blood* Sex Hormone-Binding Globulin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG1094/AG/NIA NIH HHS; M01-RR-00037/RR/NCRR NIH HHS; R01-69334//PHS HHS; T32 CA09661/CA/NCI NIH HHS; T32EF07262//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Sex Hormone-Binding Globulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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