Document Detail

Effect of exercise on serum concentration of cartilage oligomeric matrix protein in Thoroughbreds.
MedLine Citation:
PMID:  17269877     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate changes in serum cartilage oligomeric matrix protein (COMP) concentrations in response to exercise in horses. ANIMALS: 15 horses in experiment 1 and 27 horses in experiment 2. PROCEDURES: In experiment 1, 15 Thoroughbreds free of orthopedic disease underwent a standardized exercise protocol. Running velocity and heart rate (HR) were recorded, and blood samples were collected immediately before (baseline) and 1, 5, and 24 hours after a single episode of exercise. In experiment 2, 27 horses underwent 9 stages of a training program in which each stage consisted of 4 to 8 consecutive daily workouts followed by a rest day. Blood samples were collected immediately before the first and final daily workouts in each stage. Serum COMP concentrations were measured via inhibition ELISA with a monoclonal antibody (14G4) against equine COMP. RESULTS: In experiment 1, mean serum COMP concentration was significantly higher than baseline 1 and 5 hours after exercise and returned to baseline concentrations 24 hours after exercise. Mean serum baseline COMP concentration increased as the velocity of running at maximum HR and at an HR of 200 beats/min increased, being significantly higher during the third and fourth exercise tests than during the first. In experiment 2, mean baseline COMP concentration at the final workout of each stage was significantly higher than that at the first workout, beginning with stage 3. CONCLUSIONS AND CLINICAL RELEVANCE: Serum COMP concentrations changed significantly in response to exercise. Exercise may enhance movement of COMP into the circulation as well as change the basal turnover rate of COMP.
Ibrahim E Helal; Kazuhiro Misumi; Oki Tateno; Takeshi Kodama; Mutsuki Ishimaru; Junya Yamamoto; Daiske Miyakoshi; Makoto Fujiki
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  68     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
Department of Veterinary Surgery, Kagoshima University, 21-24 Korimoto 1-chome, Kagoshima 890-0065, Japan.
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MeSH Terms
Extracellular Matrix Proteins / blood*
Gene Expression Regulation
Glycoproteins / blood*
Horse Diseases / blood,  metabolism
Horses / blood*,  physiology*
Joint Diseases / blood,  metabolism
Physical Conditioning, Animal / physiology*
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/cartilage matrix protein

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