| Effect of exercise on reactivity and motor behaviour in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 20478845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Following cued levodopa (LD) intake, endurance exercise showed a beneficial effect on scored motor performance in patients with Parkinson's disease (PD) in comparison with rest. This may result from an exercise induced increase in endogenous dopamine synthesis. As a result, beneficial effects on movement and reactivity may occur. OBJECTIVES: To measure reactivity and motor performance in a repeated fashion with instrumental tasks after cued administration of soluble 200 mg of LD/50 mg of benserazide. DESIGN: PD patients consecutively performed paradigms, which assess reactivity and movement performance, after a standardised period of rest or of age-related, heart rate adapted endurance exercise on two consecutive days in a random order. RESULTS: Reactivity and execution of simple and complex motion series were significantly better following exercise than after rest. DISCUSSION: Endurance exercise has a beneficial effect on reactivity and movement behaviour in PD patients following cued application of LD probably due to an augmented synthesis and release of dopamine and other catecholamines and release in the prefrontal cortex, the nucleus accumbens and the basal ganglia. Small changes in catecholamine modulation of prefrontal cortex cells can have profound effects on the ability of the prefrontal cortex to guide behaviour. Previous exercise may also improve pedunculopontine nucleus function, which is involved in motor-related attention processes. |
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Authors:
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Thomas Müller; Siegfried Muhlack |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-05-16 |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 81 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 747-53 Citation Subset: IM |
Affiliation:
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Department of Neurology, St Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13 088 Berlin, Germany. th.mueller@alexius.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antiparkinson Agents / therapeutic use Attention / physiology Basal Ganglia / physiopathology Benserazide / therapeutic use Dopamine / physiology Dopamine Agents / therapeutic use Executive Function / physiology* Exercise Test Exercise Therapy* Female Head Movements / physiology Heart Rate / physiology Humans Male Middle Aged Movement / physiology* Parkinson Disease / drug therapy, physiopathology*, therapy* Physical Endurance / physiology Physical Fitness Pilot Projects Prefrontal Cortex / physiopathology Psychomotor Performance / physiology Reaction Time / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Dopamine Agents; 322-35-0/Benserazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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