Document Detail

Effect of exercise on reactivity and motor behaviour in patients with Parkinson's disease.
MedLine Citation:
PMID:  20478845     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Following cued levodopa (LD) intake, endurance exercise showed a beneficial effect on scored motor performance in patients with Parkinson's disease (PD) in comparison with rest. This may result from an exercise induced increase in endogenous dopamine synthesis. As a result, beneficial effects on movement and reactivity may occur. OBJECTIVES: To measure reactivity and motor performance in a repeated fashion with instrumental tasks after cued administration of soluble 200 mg of LD/50 mg of benserazide. DESIGN: PD patients consecutively performed paradigms, which assess reactivity and movement performance, after a standardised period of rest or of age-related, heart rate adapted endurance exercise on two consecutive days in a random order. RESULTS: Reactivity and execution of simple and complex motion series were significantly better following exercise than after rest. DISCUSSION: Endurance exercise has a beneficial effect on reactivity and movement behaviour in PD patients following cued application of LD probably due to an augmented synthesis and release of dopamine and other catecholamines and release in the prefrontal cortex, the nucleus accumbens and the basal ganglia. Small changes in catecholamine modulation of prefrontal cortex cells can have profound effects on the ability of the prefrontal cortex to guide behaviour. Previous exercise may also improve pedunculopontine nucleus function, which is involved in motor-related attention processes.
Thomas Müller; Siegfried Muhlack
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-05-16
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  81     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  747-53     Citation Subset:  IM    
Department of Neurology, St Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13 088 Berlin, Germany.
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MeSH Terms
Antiparkinson Agents / therapeutic use
Attention / physiology
Basal Ganglia / physiopathology
Benserazide / therapeutic use
Dopamine / physiology
Dopamine Agents / therapeutic use
Executive Function / physiology*
Exercise Test
Exercise Therapy*
Head Movements / physiology
Heart Rate / physiology
Middle Aged
Movement / physiology*
Parkinson Disease / drug therapy,  physiopathology*,  therapy*
Physical Endurance / physiology
Physical Fitness
Pilot Projects
Prefrontal Cortex / physiopathology
Psychomotor Performance / physiology
Reaction Time / physiology
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dopamine Agents; 322-35-0/Benserazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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