Document Detail

Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma.
MedLine Citation:
PMID:  12358351     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a ramp-like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean+/-SD: -9+/-6% versus -10+/-4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (-11% and -17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.
B Chenuel; P Haouzi; P Olivier; P Y Marie; B Chalon; J Borrelly
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  20     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-02     Completed Date:  2003-01-30     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  710-6     Citation Subset:  IM    
Service d'Exploration Fonctionnelle Respiratoire et Laboratoire de Physiologie, Faculté de Médecine de Nancy, France.
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MeSH Terms
Adenocarcinoma / physiopathology,  radionuclide imaging
Carcinoma, Bronchogenic / physiopathology*,  radionuclide imaging
Carcinoma, Squamous Cell / physiopathology,  radionuclide imaging
Exercise Test*
Forced Expiratory Volume
Lung / radionuclide imaging*
Lung Neoplasms / physiopathology*,  radionuclide imaging
Middle Aged
Pulmonary Circulation
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Aggregated Albumin / diagnostic use
Ventilation-Perfusion Ratio*
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Aggregated Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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