Document Detail

Effect of exercise on the kidney of aging mice.
MedLine Citation:
PMID:  2759836     Owner:  NLM     Status:  MEDLINE    
Quantitative light microscopic and ultrastructural kidney changes were studied in young and old mice subjected to moderate exercise. While there was little or no change in the glomeruli of the young animals, the older age-group showed progressive and statistically significant mesangial sclerosis with obliteration of capillary lumina. Electron microscopy also showed electron dense deposits in both the mesangium and subendothelium. Kidney weight in the young mice subjected to exercise was decreased when compared with the controls, while old animals showed a higher kidney weight after 6 weeks of running exercise. Our results of progressive kidney changes in old exercising animals, together with previous studies on myocardial and skeletal muscle showing parallel changes, stress the need for careful clinical studies on the possible damage of these organs in older people who engage in jogging and heavy exercise.
C Lichtig; J Levy; D Gershon; A Z Reznick
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  25     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-14     Completed Date:  1989-09-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  376-81     Citation Subset:  IM    
Department of Pathology, Rambam Medical Center, Haifa, Israel.
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MeSH Terms
Body Weight
Glomerular Mesangium / blood supply
Kidney / pathology,  physiology*,  ultrastructure
Kidney Glomerulus / pathology,  physiology,  ultrastructure
Mice, Inbred C57BL
Organ Size
Physical Exertion*
Renal Circulation

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