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Effect of exercise intensity in the cytokine response to an acute bout of running.
MedLine Citation:
PMID:  21552156     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE:: We compared the effects of exercise intensity (EI) on the cytokine response to an acute bout of running. METHODS:: Ten males (mean ± 1SD VO2max: 56.2 ± 8.1 mL·min-·kg-) completed three, counterbalanced, 8-day trials. Following three control days, on Day 4, participants completed 60 min of running at 55%, 65% and 75% VO2max. The cytokines tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-1 receptor antagonist (ra), and creatine kinase (CK) were measured during and for 3 h after exercise, and on four follow-up days (FU1-FU4). RESULTS:: Respiratory exchange ratio (RER) was higher at 75% VO2max compared with both 55% (P<0.001) and 65% (P<0.01) VO2max. IL-1β was undetectable in 6 participants. There was a small (18-27%) increase in TNF-a during exercise but no effect of EI. IL-6 concentrations peaked at the end of exercise, with a greater increase at 75% VO2max resulting in higher concentrations at the end of exercise and at 30 min post-exercise compared with 55% (P<0.001) and 65% VO2max (P<0.01). IL-1ra concentrations peaked at the end of exercise at 75% VO2max resulting in higher (P<0.05) concentrations at 1-2 h post-exercise compared with 55% and 65% VO2max. CK was increased at FU1 and FU2 but there was no effect of EI. CONCLUSIONS:: 60 min of treadmill running at 75% VO2max results in a greater increase in IL-6 but not TNF-α compared with 55% and 65% VO2max. The higher IL-1ra concentrations at 75% VO2max might be related to the higher IL-6 concentrations that precede them.
Authors:
Jonathan P R Scott; Craig Sale; Julie P Greeves; Anna Casey; John Dutton; William D Fraser
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-4
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Human Protection and Performance Enhancement, QinetiQ, Farnborough, UK; 2Biomedical, Life and Health Sciences Research Centre, School of Science and Technology, Nottingham Trent University, UK; 3Plans Branch, HQ Army Recruiting and Training Division, Upavon, UK; 4Department of Musculoskeletal Biology, University of Liverpool, UK.
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