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Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus.
MedLine Citation:
PMID:  21726280     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims:  Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO(2)  max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods:  We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results:  Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO(2)  max values. At 60%, only three patients showed microalbuminuria in excess of 20 μg/min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions:  Microalbuminuria increased with exercise intensity. Sex, body composition and VO(2)  max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.
Authors:
C Kornhauser; J-M Malacara; M-H Macías-Cervantes; A-E Rivera-Cisneros
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-4
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  -     ISSN:  1464-5491     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal compilation © 2011 Diabetes UK.
Affiliation:
Departamento de Ciencias Médicas División de Ciencias de la Salud, Universidad de Guanajuato, León, México.
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