| Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. | |
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MedLine Citation:
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PMID: 19211823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exercise intensity may affect the selective loss of abdominal adipose tissue. OBJECTIVE: This study showed whether aerobic exercise intensity affects the loss of abdominal fat and improvement in cardiovascular disease risk factors under conditions of equal energy deficit in women with abdominal obesity. DESIGN: This was a randomized trial in 112 overweight and obese [body mass index (in kg/m(2)): 25-40; waist circumference >88 cm], postmenopausal women assigned to one of three 20-wk interventions of equal energy deficit: calorie restriction (CR only), CR plus moderate-intensity aerobic exercise (CR + moderate-intensity), or CR plus vigorous-intensity exercise (CR + vigorous-intensity). The diet was a controlled program of underfeeding during which meals were provided at individual calorie levels (approximately 400 kcal/d). Exercise (3 d/wk) involved treadmill walking at an intensity of 45-50% (moderate-intensity) or 70-75% (vigorous-intensity) of heart rate reserve. The primary outcome was abdominal visceral fat volume. RESULTS: Average weight loss for the 95 women who completed the study was 12.1 kg (+/-4.5 kg) and was not significantly different across groups. Maximal oxygen uptake ( O(2)max) increased more in the CR + vigorous-intensity group than in either of the other groups (P < 0.05). The CR-only group lost relatively more lean mass than did either exercise group (P < 0.05). All groups showed similar decreases in abdominal visceral fat (approximately 25%; P < 0.001 for all). However, changes in visceral fat were inversely related to increases in O(2)max (P < 0.01). Changes in lipids, fasting glucose or insulin, and 2-h glucose and insulin areas during the oral-glucose-tolerance test were similar across treatment groups. CONCLUSION: With a similar amount of total weight loss, lean mass is preserved, but there is not a preferential loss of abdominal fat when either moderate- or vigorous-intensity aerobic exercise is performed during caloric restriction. This trial was registered at (ClinicalTrials.gov) as: NCT00664729. |
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Authors:
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Barbara J Nicklas; Xuewen Wang; Tongjian You; Mary F Lyles; Jamehl Demons; Linda Easter; Michael J Berry; Leon Lenchik; J Jeffrey Carr |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-02-11 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 89 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-19 Completed Date: 2009-04-06 Revised Date: 2011-04-22 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1043-52 Citation Subset: AIM; IM |
Affiliation:
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Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. bnicklas@wfubmc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00664729 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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anatomy & histology,
metabolism* Aged Area Under Curve Blood Glucose / metabolism Body Composition / physiology* Caloric Restriction Diet, Reducing* Exercise / physiology* Female Glucose Tolerance Test Humans Middle Aged Obesity / epidemiology, physiopathology, therapy* Overweight / epidemiology, physiopathology, therapy Oxygen Consumption Postmenopause Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 07122/RR/NCRR NIH HHS; M01 RR007122-130221/RR/NCRR NIH HHS; M01 RR007122-140221/RR/NCRR NIH HHS; M01 RR007122-150221/RR/NCRR NIH HHS; M01 RR007122-165684/RR/NCRR NIH HHS; M01 RR007122-178329/RR/NCRR NIH HHS; P30 AG 21332/AG/NIA NIH HHS; P30 AG021332-069011/AG/NIA NIH HHS; R01 AG/DK 20583/AG/NIA NIH HHS; R01 AG020583-01/AG/NIA NIH HHS; R01 AG020583-02/AG/NIA NIH HHS; R01 AG020583-02S1/AG/NIA NIH HHS; R01 AG020583-03/AG/NIA NIH HHS; R01 AG020583-03S1/AG/NIA NIH HHS; R01 AG020583-04/AG/NIA NIH HHS; R01 AG020583-05/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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