| Effect of exercise intensities on free fatty acid uptake in whole-body organs measured with (123)I-BMIPP-SPECT. | |
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MedLine Citation:
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PMID: 18654795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our purpose was to evaluate the effects of exercise intensities on free fatty acid (FFA) uptake in skeletal muscles, myocardium and liver among humans using (123)I-labeled 15-(p-iodophenyl)-3-(R,S)-methyl-pentadecanoic acid ((123)I-BMIPP) and single photon emission computed tomography technique (SPECT). Six untrained male subjects were studied after 35 min of ergometer bicycle exercise at 40, 70 and 80% maximal aerobic power (VO(2max)) One subject was studied as resting control. SPECT scan was done 40 min after (123)I-BMIPP injection. Mean fractional uptake (FU) in quadriceps femoris muscle (QF) were 0.029 +/- 0.001, 0.029 +/- 0.002 and 0.025 +/- 0.002% at 40, 70 and 80% VO(2max), respectively. FU of QF at 40 and 70% VO(2max) were significantly higher than those of 80% VO(2max). Mean FU into myocardium were 0.048 +/- 0.002, 0.052 +/- 0.004 and 0.050 +/- 0.003% and those in liver were 0.033 +/- 0.002, 0.032 +/- 0.002 and 0.034 +/- 0.003% at each loads, respectively. Any significant changes were not suggestive in liver and myocardium after exercise. Mean FU (the mean values of all exercise intensity) at exercise is 2.86, 0.96 and 0.71 times higher than those at rest in QF, myocardium and liver. These results suggest: (1) in skeletal muscles, energy requirements at above lactate threshold at high exercise intensity predominantly depend upon other intramuscular energy substrates, (2) there is possibility of energy compensation by other substrates in myocardium at higher exercise intensity, (3) FFA uptake in liver might decrease after exercise; however, the influence of exercise intensities is not suggested. |
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Authors:
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Koji Kitada; Kazuo Kubota; Ryoichi Nagatomi; Masatoshi Itoh; Manabu Tashiro; Hiroshi Fukuda; Mehedi Masud; Toshihiko Fujimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-25 |
Journal Detail:
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Title: European journal of applied physiology Volume: 104 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2008-12-16 Revised Date: 2009-01-07 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 769-75 Citation Subset: IM |
Affiliation:
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Department of Medicine and Science in Sports and Exercise, Graduate School of Medicine, Tohoku University, Sendai 980-8576, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Energy Metabolism* Exercise / physiology* Fatty Acids / administration & dosage, pharmacokinetics* Fatty Acids, Nonesterified / metabolism* Heart / radionuclide imaging Humans Injections, Intravenous Iodine Radioisotopes Iodobenzenes / administration & dosage, pharmacokinetics* Liver / metabolism*, radionuclide imaging Male Muscle Contraction Muscle, Skeletal / metabolism*, radionuclide imaging Myocardium / metabolism* Oxygen Consumption Tomography, Emission-Computed, Single-Photon* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Iodine Radioisotopes; 0/Iodobenzenes; 116754-87-1/iodofiltic acid |
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