Document Detail


Effect of exercise and food restriction on selected markers of the acute phase response in hamsters.
MedLine Citation:
PMID:  7759413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute aerobic exercise has been shown to elicit physiological changes characteristic of the acute phase response (APR), a nonspecific host defense response. Regular evocation of these changes may prime the immune system to improve resistance to disease. Because food deprivation is associated with an impaired APR, food restriction may prevent these beneficial changes. We tested the hypotheses that voluntary exercise elicits an APR and that food restriction modifies this response in four groups of hamsters: ad libitum-fed sedentary, ad libitum-fed exercised, food-restricted sedentary, and food-restricted exercised. Five variables altered during an APR were examined: core temperature, serum iron, serum interleukin-6, serum amyloid A, and serum glucocorticoids measured by biotelemetry, colorimetric analysis, B-9 cell growth assay, indirect enzyme-linked immunosorbent assay, and radioimmunoassay, respectively. Blood was drawn during the hamsters' inactive period after 19-20 days of access to running wheels. Resting core temperature was elevated by exercise and depressed by food restriction (P < 0.01). Iron was depressed by food restriction (P < 0.01). Cortisol, but not corticosterone, was elevated by food restriction (P < 0.001). There were no significant differences among groups in interleukin-6 (P > 0.49) or serum amyloid A (P > 0.29). We conclude that there is little evidence that voluntary exercise or exercise combined with food restriction causes an APR in hamsters.
Authors:
C A Conn; W E Kozak; P C Tooten; T A Niewold; K T Borer; M J Kluger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  78     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  458-65     Citation Subset:  IM    
Affiliation:
Institute for Basic and Applied Medical Research, Lovelace Institutes, Albuquerque, New Mexico 87108, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Reaction / physiopathology*
Amyloid / blood
Animals
Body Temperature / physiology
Body Weight / physiology
Corticosterone / blood
Cricetinae
Eating / physiology*
Female
Hydrocortisone / blood
Interleukin-6 / metabolism
Iron / blood
Mesocricetus
Motor Activity / physiology
Physical Exertion / physiology*
Grant Support
ID/Acronym/Agency:
AI-27556/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid; 0/Interleukin-6; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 7439-89-6/Iron

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