| Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. | |
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MedLine Citation:
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PMID: 18239078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many epidemiological studies have demonstrated that level of exercise is associated with reduced colorectal cancer risk. Treadmill training can decrease Apc(Min/+) mouse intestinal polyp number and size, but the mechanisms remain unclear. Understanding the molecular changes in the tumor following exercise training may provide insight on the mechanism by which exercise decreases Apc(Min/+) mouse polyp formation and growth. The purpose of this study was to determine if exercise can modulate Apc(Min/+) mouse intestinal polyp cellular signaling related to tumor formation and growth. Male Apc(Min/+) mice were randomly assigned to control (n = 20) or exercise (n = 20) treatment groups. Exercised mice ran on a treadmill at a moderate intensity (18 m/min, 60 min, 6 days/wk, 5% grade) for 9 wk. Polyps from Apc(Min/+) mice were used to quantify markers of polyp inflammation, apoptosis, and beta-catenin signaling. Exercise decreased the number of macrophages in polyps by 35%. Related to apoptosis, exercise decreased the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells by 73% in all polyps. Bax protein expression in polyps was decreased 43% by exercise. beta-Catenin phosphorylation was elevated 3.3-fold in polyps from exercised mice. Moderate-intensity exercise training alters cellular pathways in Apc(Min/+) mouse polyps, and these changes may be related to the exercise-induced reduction in polyp formation and growth. |
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Authors:
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Kristen A Baltgalvis; Franklin G Berger; Maria Marjorette O Peña; J Mark Davis; James A Carson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-01-31 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-06-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1137-43 Citation Subset: IM |
Affiliation:
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Univ. of South Carolina, Dept. of Exercise Science, Rm. 405A Public Health Research Bldg., 921 Assembly St., Columbia, SC 29208, USA. carsonj@sc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenomatous Polyposis Coli
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genetics*,
pathology* Animals Apoptosis / physiology Blotting, Western Cyclooxygenase 2 / biosynthesis, genetics Immunohistochemistry In Situ Nick-End Labeling Inflammation / pathology, physiopathology Macrophages / physiology Male Mice Mice, Knockout Neutrophil Infiltration / physiology Phosphorylation Physical Conditioning, Animal / physiology* Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / physiology bcl-2-Associated X Protein / biosynthesis, genetics beta Catenin / biosynthesis, genetics |
| Grant Support | |
ID/Acronym/Agency:
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P20-RR-017698/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/bcl-2-Associated X Protein; 0/beta Catenin; EC 1.14.99.1/Cyclooxygenase 2; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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