Document Detail

Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps.
MedLine Citation:
PMID:  18239078     Owner:  NLM     Status:  MEDLINE    
Many epidemiological studies have demonstrated that level of exercise is associated with reduced colorectal cancer risk. Treadmill training can decrease Apc(Min/+) mouse intestinal polyp number and size, but the mechanisms remain unclear. Understanding the molecular changes in the tumor following exercise training may provide insight on the mechanism by which exercise decreases Apc(Min/+) mouse polyp formation and growth. The purpose of this study was to determine if exercise can modulate Apc(Min/+) mouse intestinal polyp cellular signaling related to tumor formation and growth. Male Apc(Min/+) mice were randomly assigned to control (n = 20) or exercise (n = 20) treatment groups. Exercised mice ran on a treadmill at a moderate intensity (18 m/min, 60 min, 6 days/wk, 5% grade) for 9 wk. Polyps from Apc(Min/+) mice were used to quantify markers of polyp inflammation, apoptosis, and beta-catenin signaling. Exercise decreased the number of macrophages in polyps by 35%. Related to apoptosis, exercise decreased the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells by 73% in all polyps. Bax protein expression in polyps was decreased 43% by exercise. beta-Catenin phosphorylation was elevated 3.3-fold in polyps from exercised mice. Moderate-intensity exercise training alters cellular pathways in Apc(Min/+) mouse polyps, and these changes may be related to the exercise-induced reduction in polyp formation and growth.
Kristen A Baltgalvis; Franklin G Berger; Maria Marjorette O Peña; J Mark Davis; James A Carson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-01-31
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1137-43     Citation Subset:  IM    
Univ. of South Carolina, Dept. of Exercise Science, Rm. 405A Public Health Research Bldg., 921 Assembly St., Columbia, SC 29208, USA.
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MeSH Terms
Adenomatous Polyposis Coli / genetics*,  pathology*
Apoptosis / physiology
Blotting, Western
Cyclooxygenase 2 / biosynthesis,  genetics
In Situ Nick-End Labeling
Inflammation / pathology,  physiopathology
Macrophages / physiology
Mice, Knockout
Neutrophil Infiltration / physiology
Physical Conditioning, Animal / physiology*
Proto-Oncogene Proteins c-akt / metabolism
Signal Transduction / physiology
bcl-2-Associated X Protein / biosynthesis,  genetics
beta Catenin / biosynthesis,  genetics
Grant Support
Reg. No./Substance:
0/bcl-2-Associated X Protein; 0/beta Catenin; EC 2; EC Proteins c-akt

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