Document Detail

Effect of exercise associated with stem cell transplantation on ventricular function in rats after acute myocardial infarction.
MedLine Citation:
PMID:  23515727     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To analyze the functional and anatomical-pathological effect of transplantation of bone marrow mononuclear cells associated to aquatic physical activity after myocardial infarction in rats. METHODS: Twenty-one rats were induced by myocardial infarction, through left coronary artery ligation. After a week, the animals were subjected to echocardiography for evaluation of left ventricle ejection fraction (LVEF, %) and dyastolic and end systolic volume of the left ventricle (EDV, ESV, ml), randomized and the transplantation of mononuclear stem cells. The animals were divided into four groups: sedentary group without cells (n=5), sedentary with cells (n=5), trained without cells (n=5) and trained with cells (n=6). The physical training was started 30 days after infarction and held in swimming during 30 days. At the beginning and at the end of the physical training protocol were held assay of lactate. The animals have been subjected to new echocardiography after 60 days of myocardial infarction. RESULTS: Two months after the transplant, were observed decrease in FE in the control group (35.2 to 23.54 P=0.022) and addition of LVEF and stabilization of ventricular remodeling in the group trained with cells (29.85 to 33.43% P=0.062 and 0.71 to 0.73 ml, P=0.776, respectively). Identified the reduction of collagen fibers, myocardial fibrosis regions in the group trained with and without cells. CONCLUSION: The group trained with cells improves ventricular function compared to the control group, suggesting the benefit of associated cell therapy will physical activity.
Simone Cosmo; Julio César Francisco; Ricardo Correa da Cunha; Rafael Michel de Macedo; José Rocha Faria-Neto; Rossana Simeoni; Katherine Athayde Teixeira de Carvalho; Marcia Olandoski; Nelson Itiro Miyague; Vivian Ferreira do Amaral; Luiz César Guarita-Souza
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Publication Detail:
Journal Detail:
Title:  Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular     Volume:  27     ISSN:  1678-9741     ISO Abbreviation:  Rev Bras Cir Cardiovasc     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104279     Medline TA:  Rev Bras Cir Cardiovasc     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  542-551     Citation Subset:  -    
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil.
Vernacular Title:
Efeito do exercício associado ao transplante de células-tronco sobre a função ventricular de ratos pós-infarto agudo do miocárdio.
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