Document Detail

Effect of exercise on acid-base status and ventilatory kinetics.
MedLine Citation:
PMID:  9741659     Owner:  NLM     Status:  MEDLINE    
The normal respiratory responses and changes in acid base status in twenty normal height, weight and age matched subjects were studied; using Auto Spiro AS 300 spirometer for ventilatory parameters and NOVA stat profile 3 analyser for gas analysis. Each subject performed a progressive incremental treadmill exercise by Bruce protocol to their symptom limited maximum. Minute ventilation (VE), tidal volume (VT) and frequency of respiration (f) increased significantly (P<0.001). Acidosis occured following exercise as pH of arterialized venous blood declined significantly (P<0.05). Gas analysis of arterialized venous blood showed a rise in pO2 (P<0.001) and a fall in pCO2 (P<0.001). Recovery of acid base status as well as gaseous pressure in blood did not occur after 10 min. Expired gas pCO2 declined significantly (P<0.05) and pO2 increase significantly (P<0.05). These pressures returned to resting levels 10 min after exercise. Thus in normal young adults heavy exercise caused an increment in ventilatory kinetics producing hyperpnoea which recovers after a rest of 10 min. Acidosis stimulates the respiratory centre to cause hyperventilation which tries to meet the added metabolic demands of strenuous exercise.
M S Phatak; G A Kurhade; S B Kaore; G C Pradhan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  42     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  417-20     Citation Subset:  IM    
Department of Physiology, Govt. Medical College, Nagpur.
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MeSH Terms
Carbon Dioxide
Exercise / physiology*
Lung / physiology*
Pulmonary Ventilation*
Respiratory Function Tests
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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