Document Detail

Effect of exclusive enteral nutrition on gut microflora function in children with Crohn's disease.
MedLine Citation:
PMID:  23016828     Owner:  NLM     Status:  Publisher    
Abstract Objective. Exclusive enteral nutrition (EEN) is a first-line treatment in children with active Crohn's disease (CD) but is seldom used in adults with active disease. The mode of action of EEN in suppressing mucosal inflammation is not fully understood, but modulation of intestinal microflora activity is one possible explanation. The aim of this study was to investigate the effect of 6-week EEN in children with active CD, with special reference to intestinal microflora function. Materials and methods. Fecal samples from 18 children (11 boys, 7 girls; median age 13.5 years) with active CD (13 children with small bowel/colonic and 5 with perianal disease) were analyzed for short chain fatty acid (SCFA) pattern as marker of gut microflora function. The children were studied before and after EEN treatment. Results from 12 healthy teenagers were used for comparison. Results. Eleven (79%) of the children with small bowel/colonic CD responded clinically positively to EEN treatment showing decreased levels of pro-inflammatory acetic acid as well as increased concentrations of anti-inflammatory butyric acids and also of valeric acids, similar to the levels in healthy age-matched children. In children with active perianal CD, however, EEN had no positive effect on clinical status or inflammatory parameters. Conclusions. The authors present new data supporting the hypothesis that the well-documented anti-inflammatory effect of EEN in children with active small bowel/colonic CD is brought about by modulation of gut microflora activity, resulting in an anti-inflammatory SCFA pattern. By contrast, none of the children with perianal disease showed clinical or biochemical improvement after EEN treatment.
Bo Tjellström; Lotta Högberg; Lars Stenhammar; Karl-Eric Magnusson; Tore Midtvedt; Elisabeth Norin; Tommy Sundqvist
Related Documents :
23031188 - Examining the validity of the activpal monitor in measuring posture and ambulatory move...
22682908 - Enhanced efficiency of the executive attention network after training in preschool chil...
8464668 - Issues involved in the definition and classification of chronic health conditions.
23360568 - Antioxidant enzymes activities in obese tunisian children.
19584188 - Impact of the exon 3-deleted growth hormone (gh) receptor polymorphism on baseline heig...
12530728 - Identification and remediation of reading difficulties based on successive processing d...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  -     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Microbiology, Karolinska Institute, Tumor and Cell Biology , Stockholm , Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The power of a handshake: neural correlates of evaluative judgments in observed social interactions.
Next Document:  Alteration of global workspace during loss of consciousness: A study of parietal seizures.