| Effect of excess phenylacetate diet during pregnancy on fetal brain growth in rats. | |
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MedLine Citation:
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PMID: 8184410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of phenylacetate (PA) on fetal brain growth were examined in pregnant rats receiving a 20% casein diet with 1.0, 1.5, 2.0 or 2.5% PA. Control rats were fed the 20% casein diet ad libitum or restricted to daily consumption of 9 and 6 g. In experimental groups of rats total food intake during pregnancy decreased, however the decrease was not so large as we had expected. By plotting the fetal brain weight (Y, mg) against maternal food intake (X, g/21 days) in control groups the following hyperbolic regression equation was obtained: Y = -4243/X + 124.6 (n: 18, r = 0.80, p < 0.001). Similar plots for excess PA rats fell below this line, indicating that prenatal fetal brain growth was impaired by an excess in PA per se specifically, as well as by decreased food intake nonspecifically. Administering the excess PA diets resulted in decreases in total RNA, total protein and RNA/DNA ratio in the fetal brain, whereas total DNA was unchanged, showing the impairment of protein synthesis, not proliferation. No remarkable changes in concentration and pattern of free amino acids in maternal plasma in excess PA groups were observed. Using a relation between total food intake during pregnancy and fetal brain weight, the extent of specific and nonspecific effects of excess PA and phenylalanine on brain growth was compared. |
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Authors:
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S Manabe; K Ohsawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tokushima journal of experimental medicine Volume: 40 ISSN: 0040-8875 ISO Abbreviation: Tokushima J. Exp. Med. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-06-14 Completed Date: 1994-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417356 Medline TA: Tokushima J Exp Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 137-45 Citation Subset: IM |
Affiliation:
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Department of Nutrition, School of Medicine, University of Tokushima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis,
blood Animal Feed Animals Body Weight / drug effects Brain / drug effects, embryology* Brain Chemistry Eating / drug effects Female Fetal Growth Retardation / chemically induced Organ Size / drug effects Phenylacetates / administration & dosage, analysis, pharmacology* Pregnancy Rats Rats, Sprague-Dawley Reproduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Phenylacetates; 103-82-2/phenylacetic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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