| Effect of etonogestrel contraceptive implant (Implanon) on portal blood flow and liver functions. | |
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MedLine Citation:
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PMID: 19185679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study was conducted to evaluate changes in portal blood flow and liver functions among women using Implanon for 2 years. STUDY DESIGN: Fifty healthy Implanon users were enrolled in this longitudinal study and followed up for 24 months. Portal blood flow, assessed by color Doppler; prothrombin time and concentration; serum albumin; bilirubin; gamma-glutamyl transferase (GGT); alanine aminotransferase (ALT); and aspartate aminotransferase (AST) were measured before and 24 months after insertion. RESULTS: After 24 months of Implanon insertion, there were no significant changes in portal blood flow, serum albumin, prothrombin time or concentration. However, there was a significant increase in serum levels of total and unconjugated bilirubin and GGT and a significant decrease in ALT and AST levels. All levels, however, remained within the normal range of values. CONCLUSIONS: Implanon use for 2 years does not seem to influence portal hemodynamics. Changes in serum levels of bilirubin, GGT, ALT and AST are unlikely to be of clinical significance. |
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Authors:
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Ahmed Nasr; Hanan M Nafeh |
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Publication Detail:
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Type: Journal Article Date: 2008-10-28 |
Journal Detail:
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Title: Contraception Volume: 79 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 236-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Assiut University, 71516 Assiut, Egypt. a_nasr02@lycos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contraceptive Agents, Female / pharmacology* Desogestrel / pharmacology* Female Humans Liver / drug effects* Liver Circulation / drug effects* Liver Function Tests Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contraceptive Agents, Female; 54024-22-5/Desogestrel; 54048-10-1/3-keto-desogestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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