Document Detail


Effect of ethyl icosapentate on urinary calcium and oxalate excretion.
MedLine Citation:
PMID:  11144503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The effect of ethyl icosapentate (EPA-E) on urinary calcium and oxalic acid excretion was examined to evaluate whether EPA-E is useful in the prevention of calcium-containing urinary stones. METHODS: For 6 months, urine was measured daily from 40 calcium-containing urinary stone producers at an outpatient clinic, before and after the administration of 1800 mg/day EPA-E. The urine was measured for volume, urea nitrogen, creatinine, calcium, magnesium, phosphorus, uric acid, oxalic acid and citric acid. Serum total cholesterol and triglyceride were also measured. RESULTS: Urinary calcium excretion was not reduced in any of the patients or particular hypercalciuric groups, nor did the level of calcium change. However, nine of the 25 hypercalciuric patients experienced a significant urinary calcium reduction to the normal calciuric level (a reduction of approximately 44%). It is not known why these particular patients experienced a reduction. Urinary oxalic acid did not change, whether hypercalciuria was present or not. CONCLUSIONS: These findings suggest that EPA-E is not particularly effective in reducing urinary calcium excretion in the hypercalciuric patients, but it needs future investigation because some patients experienced significant urinary calcium reduction.
Authors:
E Konya; H Tsuji; T Umekawa; T Kurita; M Iguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  7     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-28     Completed Date:  2001-02-01     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Affiliation:
Department of Urology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan. urology@med.kindai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Urea Nitrogen
Calcium / urine*
Cholesterol / blood
Creatine / urine
Eicosapentaenoic Acid / analogs & derivatives*,  therapeutic use*
Female
Humans
Magnesium / urine
Male
Middle Aged
Oxalic Acid / urine*
Triglycerides / blood
Uric Acid / urine
Urinary Calculi / blood,  drug therapy*,  urine
Chemical
Reg. No./Substance:
0/Triglycerides; 144-62-7/Oxalic Acid; 1553-41-9/Eicosapentaenoic Acid; 57-00-1/Creatine; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 73310-10-8/eicosapentaenoic acid ethyl ester; 7439-95-4/Magnesium; 7440-70-2/Calcium

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