| Effect of ethyl icosapentate on urinary calcium and oxalate excretion. | |
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MedLine Citation:
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PMID: 11144503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effect of ethyl icosapentate (EPA-E) on urinary calcium and oxalic acid excretion was examined to evaluate whether EPA-E is useful in the prevention of calcium-containing urinary stones. METHODS: For 6 months, urine was measured daily from 40 calcium-containing urinary stone producers at an outpatient clinic, before and after the administration of 1800 mg/day EPA-E. The urine was measured for volume, urea nitrogen, creatinine, calcium, magnesium, phosphorus, uric acid, oxalic acid and citric acid. Serum total cholesterol and triglyceride were also measured. RESULTS: Urinary calcium excretion was not reduced in any of the patients or particular hypercalciuric groups, nor did the level of calcium change. However, nine of the 25 hypercalciuric patients experienced a significant urinary calcium reduction to the normal calciuric level (a reduction of approximately 44%). It is not known why these particular patients experienced a reduction. Urinary oxalic acid did not change, whether hypercalciuria was present or not. CONCLUSIONS: These findings suggest that EPA-E is not particularly effective in reducing urinary calcium excretion in the hypercalciuric patients, but it needs future investigation because some patients experienced significant urinary calcium reduction. |
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Authors:
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E Konya; H Tsuji; T Umekawa; T Kurita; M Iguchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: 7 ISSN: 0919-8172 ISO Abbreviation: Int. J. Urol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-28 Completed Date: 2001-02-01 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: Australia |
Other Details:
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Languages: eng Pagination: 361-5 Citation Subset: IM |
Affiliation:
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Department of Urology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan. urology@med.kindai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Urea Nitrogen Calcium / urine* Cholesterol / blood Creatine / urine Eicosapentaenoic Acid / analogs & derivatives*, therapeutic use* Female Humans Magnesium / urine Male Middle Aged Oxalic Acid / urine* Triglycerides / blood Uric Acid / urine Urinary Calculi / blood, drug therapy*, urine |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 144-62-7/Oxalic Acid; 1553-41-9/Eicosapentaenoic Acid; 57-00-1/Creatine; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 73310-10-8/eicosapentaenoic acid ethyl ester; 7439-95-4/Magnesium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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