| Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis. | |
| | |
MedLine Citation:
|
PMID: 9065300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The objective of this study was to investigate the effects of ethanol on pancreatic blood flow and interstitial pH in chronic pancreatitis. BACKGROUND: Ethanol is known to contribute to the development of both acute and chronic pancreatitis. However, it is unclear how ethanol precipitates episodes of acute pancreatic inflammation in the setting of chronic pancreatitis. In a model of chronic pancreatitis in cats, it is known that pancreatic blood flow is abnormally low and decreases further after ethanol ingestion. Because it is possible that this reduction in blood flow might be damaging to the pancreas, we investigated the effects of ethanol on pancreatic interstitial pH, an index of pancreatic ischemia. METHODS: In normal cats and cats with obstructive chronic pancreatitis, pancreatic blood flow and interstitial pH were measured using the hydrogen gas clearance technique and pH microelectrode, respectively. RESULTS: In normal cats, intragastric, but not intravenous, ethanol reduced both pancreatic blood flow by 62% (p < 0.05) and interstitial pH (7.38 +/- 0.03 to 7.20 +/- 0.03, p < 0.05). In cats with chronic pancreatitis in which basal pancreatic blood flow was already only 60% of normal flow, both intragastric and intravenous ethanol decreased both pancreatic blood flow (intragastric, 40% decrease, p < 0.05; intravenous, 34% decrease, p < 0.05) and interstitial pH (intragastric, 7.24 +/- 0.04 to 7.08 +/- 0.04, p < 0.05; intravenous 7.20 +/- 0.08 to 7.07 +/- 0.07, p < 0.05). CONCLUSIONS: This profound decrease in pH, lasting up to 2 hours after ethanol exposure in the chronic pancreatitis animals, suggests the possibility of ischemic cellular damage to the pancreas. These findings may explain the pathogenesis of bouts of acute pancreatic inflammation after ethanol ingestion in the setting of chronic disease. |
| | |
Authors:
|
M T Toyama; A G Patel; T Nguyen; S W Ashley; H A Reber |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Annals of surgery Volume: 225 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1997 Feb |
Date Detail:
|
Created Date: 1997-03-14 Completed Date: 1997-03-14 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 223-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Sepulveda VA Medical Center, Los Angeles, California, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cats Chronic Disease Ethanol / pharmacology* Extracellular Space / drug effects*, metabolism* Female Hydrogen-Ion Concentration / drug effects Injections, Intravenous Male Pancreas / blood supply*, drug effects* Pancreatitis / metabolism* Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
|
64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Management of severe pancreatitis in renal transplant recipients.
Next Document: Sleeve recording of upper esophageal sphincter resting pressures during cricopharyngeal myotomy.