Document Detail


Effect of ethanol on myocardial infarct size in a canine model of coronary artery occlusion-reperfusion.
MedLine Citation:
PMID:  9774183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to determine if elevated blood alcohol prior to acute coronary artery occlusion affects myocardial infarct size in an in vivo canine model. Seven pentobarbital anesthetized open-chest dogs received 10 min iv infusion of ethanol (0.08 g/kg/min). Ten min after ethanol, the left anterior descending coronary artery (LAD) was occluded distal to its first major branch for 60 min. The LAD was then reperfused for 5 h. Following electrically induced ventricular fibrillation, the area at risk of infarction was delineated with dye. The area of infarction was identified by staining with triphenyl tetrazolium chloride. Eleven untreated control experiments were also conducted. Mean blood ethanol concentration was 155+/-26 mg/dl just prior to LAD occlusion and 47+/-3 mg/dl after 4 h reperfusion. Ethanol infusion had no effect on systemic hemodynamic variables during ischemia. In ethanol treated animals, the area at risk was 19.7+/-3.0% of the left ventricle, and the infarct size was 20.9 +/-4.8% of the area at risk. In control experiments, the area at risk was 23.0+/-4.1% of the left ventricle (p > 0.05), and the infarct size was 21.6+/-3.8% of the area at risk (p > 0.05). Collateral blood flow to ischemic region did not differ between the two groups, and the relationships between infarct size and collateral flow were similar for control and untreated hearts. Acute ethanol exposure prior to coronary artery occlusion and subsequent reperfusion does not affect myocardial infarct size in the heart of the anesthetized dog.
Authors:
M Itoya; J D Morrison; H F Downey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  186     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-30     Completed Date:  1998-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, 76107-2699, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Collateral Circulation / drug effects
Coloring Agents
Coronary Vessels
Disease Models, Animal
Dogs
Ethanol / administration & dosage,  blood,  pharmacology*
Female
Hemodynamics / drug effects
Male
Myocardial Infarction / etiology*,  pathology*,  prevention & control
Myocardial Reperfusion Injury / etiology*,  pathology,  physiopathology
Tetrazolium Salts
Grant Support
ID/Acronym/Agency:
HL 35027/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Tetrazolium Salts; 64-17-5/Ethanol; 902-00-1/triphenyltetrazolium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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