Document Detail

Effect of ethane-1-hydroxy-1,1-diphosphonate on ectopic bone formation induced by murine osteosarcoma-derived bone-inducing substance.
MedLine Citation:
PMID:  3094564     Owner:  NLM     Status:  MEDLINE    
The effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on ectopic bone formation were studied qualitatively and quantitatively in an experimental system for ectopic bone formation induced by murine osteosarcoma-derived bone-inducing substance. At a low dose of EHDP (3 mg/kg per day i.p.), histologic sequelae of ectopic bone formation were normal, and the size of the induced bone mass was unaffected. At a high dose of EHDP (30 mg/kg per day i.p.), an unmineralized bone matrix with hematopoietic bone marrow was formed without evidence of retardation. This osteoid tissue showed no radiologic and histologic evidence of mineralization during the period of EHDP administration. When EHDP was withdrawn, its inhibitory effect on mineralization was reversed. The induced bone mass was almost the same size as that in controls. These results suggest that EHDP might not prevent ectopic bone matrix formation, but its mineralization and withdrawal of EHDP might lead to the formation of a normal bone similar in size to that formed without EHDP treatment.
H Nakahara; H Yoshikawa; K Takaoka; K Ono
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone     Volume:  7     ISSN:  8756-3282     ISO Abbreviation:  Bone     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-10     Completed Date:  1986-12-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
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MeSH Terms
Bone Morphogenetic Proteins
Bone and Bones / anatomy & histology,  drug effects,  metabolism
Etidronic Acid / pharmacology*
Minerals / metabolism
Osteogenesis / drug effects*
Proteins / pharmacology*
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Minerals; 0/Proteins; 2809-21-4/Etidronic Acid

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