| Effect of ethane-1-hydroxy-1,1-diphosphonate on ectopic bone formation induced by murine osteosarcoma-derived bone-inducing substance. | |
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MedLine Citation:
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PMID: 3094564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on ectopic bone formation were studied qualitatively and quantitatively in an experimental system for ectopic bone formation induced by murine osteosarcoma-derived bone-inducing substance. At a low dose of EHDP (3 mg/kg per day i.p.), histologic sequelae of ectopic bone formation were normal, and the size of the induced bone mass was unaffected. At a high dose of EHDP (30 mg/kg per day i.p.), an unmineralized bone matrix with hematopoietic bone marrow was formed without evidence of retardation. This osteoid tissue showed no radiologic and histologic evidence of mineralization during the period of EHDP administration. When EHDP was withdrawn, its inhibitory effect on mineralization was reversed. The induced bone mass was almost the same size as that in controls. These results suggest that EHDP might not prevent ectopic bone matrix formation, but its mineralization and withdrawal of EHDP might lead to the formation of a normal bone similar in size to that formed without EHDP treatment. |
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Authors:
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H Nakahara; H Yoshikawa; K Takaoka; K Ono |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone Volume: 7 ISSN: 8756-3282 ISO Abbreviation: Bone Publication Date: 1986 |
Date Detail:
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Created Date: 1986-12-10 Completed Date: 1986-12-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 229-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Morphogenetic Proteins Bone and Bones / anatomy & histology, drug effects, metabolism Etidronic Acid / pharmacology* Male Mice Minerals / metabolism Osteogenesis / drug effects* Proteins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins; 0/Minerals; 0/Proteins; 2809-21-4/Etidronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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