| Effect of estrogen on sensitivity of rabbit bladder and urethra to phenylephrine. | |
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MedLine Citation:
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PMID: 567627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sensitivity of alpha-adrenoceptors to phenylephrine as indicated by the ED50 of the rabbit bladder and urethra was compared for segments in vitro from control (estrous), ovariectomized, ovariectomized-estrogen-treated, and pregnant animals. In control animals there was a trend for urethral segments to be more sensitive to phenylephrine (lower ED50) than bladder segments. This difference was abolished by castration, which decreased the sensitivity of the anular urethral segment, and by pregnancy, which tended to enhance the sensitivity of the bladder. The tension generated by bladder segments was enhanced by pregnancy and tended to be decreased by castration. The effects of castration tended to be reversed by treatment with estrogen (1 microgram per kg of body weight per day for 14 days). These data indicate that estrogen can influence the response of the urethra and urinary bladder to alpha adrenergic stimulation. |
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Authors:
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B J Hodgson; S Dumas; D R Bolling; C M Heesch |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Investigative urology Volume: 16 ISSN: 0021-0005 ISO Abbreviation: Invest Urol Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-11-22 Completed Date: 1978-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374747 Medline TA: Invest Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 67-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Castration Estradiol / pharmacology* Female Male Muscle Contraction / drug effects Muscles / physiology* Phenylephrine / pharmacology* Pregnancy Rabbits Urethra / drug effects*, innervation, physiology Urinary Bladder / drug effects*, innervation, physiology |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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