| Effect of essential fatty acid deficiency on maternal, placental, and fetal rat tissues. | |
| | |
MedLine Citation:
|
PMID: 7277037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prolonged dietary deprivation is needed to produce essential fatty acid (EFA) deficiency. But lack of EFA also impairs reproductive function. Inclusion of small amounts of linoleic acid in the diet can overcome this difficulty; further, if large amounts of oleic acid are included in the diet, this competes with the utilization of 18:2 producing EFA deficiency. Using this approach, female rats were fed a fat-free diet containing 5% oleic acid w/w (with 2-3% 18:2) as the only source of fat for 4 months. They were mated and on the 21st day of gestation, the fatty acids of fetal tissues, placenta, maternal liver and plasma were analyzed and compared to controls on a stock diet. Fetuses from the experimental group were smaller and contained higher amounts of 18:1 and 20:3 omega 9 indicating EFA deficiency. The omega 6 fatty acids in the polar lipids of placenta of the EFA-deficient group were not significantly lower than the controls, in spite of lower concentrations in the maternal plasma, suggesting a unique capacity of the placenta to concentrate omega 6 fatty acids, which in turn may be utilized for prostaglandin synthesis needed for inducing labor and other vascular changes in the fetus. |
| | |
Authors:
|
N K Menon; C Moore; G A Dhopeshwarkar |
Related Documents
:
|
3612677 - The importance of essential fatty acid evaluation and supplementation in feline diets. 8838477 - Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a gen... 3345127 - Use of nile red stain in the detection of cholesteryl ester accumulation in acid lipase... 10553487 - Estimates of essential amino acid requirements from dose-response studies with rainbow ... 7109717 - The effect of chronic ethanol administration on lipids and fatty acids in subcellular f... 2325847 - Excitatory amino acid projections to the periaqueductal gray in the rat: a retrograde t... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of nutrition Volume: 111 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1981 Sep |
Date Detail:
|
Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1602-10 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / anatomy & histology, embryology, metabolism Fatty Acids, Essential / deficiency* Female Fetus / metabolism* Lipid Metabolism* Liver / metabolism Oleic Acid Oleic Acids / administration & dosage Organ Size Placenta / anatomy & histology, metabolism* Pregnancy Pregnancy Complications / metabolism* Rats |
| Grant Support | |
ID/Acronym/Agency:
|
1 R01 NS 13755-01A1 NTN/NS/NINDS NIH HHS; HL 07386-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Essential; 0/Oleic Acids; 112-80-1/Oleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of exercise on iron and copper metabolism in rats.
Next Document: Relationship of selenium-dependent glutathione peroxidase activity and nutritional pancreatic atroph...