Document Detail

Effect of essential fatty acid deficiency on maternal, placental, and fetal rat tissues.
MedLine Citation:
PMID:  7277037     Owner:  NLM     Status:  MEDLINE    
Prolonged dietary deprivation is needed to produce essential fatty acid (EFA) deficiency. But lack of EFA also impairs reproductive function. Inclusion of small amounts of linoleic acid in the diet can overcome this difficulty; further, if large amounts of oleic acid are included in the diet, this competes with the utilization of 18:2 producing EFA deficiency. Using this approach, female rats were fed a fat-free diet containing 5% oleic acid w/w (with 2-3% 18:2) as the only source of fat for 4 months. They were mated and on the 21st day of gestation, the fatty acids of fetal tissues, placenta, maternal liver and plasma were analyzed and compared to controls on a stock diet. Fetuses from the experimental group were smaller and contained higher amounts of 18:1 and 20:3 omega 9 indicating EFA deficiency. The omega 6 fatty acids in the polar lipids of placenta of the EFA-deficient group were not significantly lower than the controls, in spite of lower concentrations in the maternal plasma, suggesting a unique capacity of the placenta to concentrate omega 6 fatty acids, which in turn may be utilized for prostaglandin synthesis needed for inducing labor and other vascular changes in the fetus.
N K Menon; C Moore; G A Dhopeshwarkar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  111     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1602-10     Citation Subset:  IM    
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MeSH Terms
Brain / anatomy & histology,  embryology,  metabolism
Fatty Acids, Essential / deficiency*
Fetus / metabolism*
Lipid Metabolism*
Liver / metabolism
Oleic Acid
Oleic Acids / administration & dosage
Organ Size
Placenta / anatomy & histology,  metabolism*
Pregnancy Complications / metabolism*
Grant Support
1 R01 NS 13755-01A1 NTN/NS/NINDS NIH HHS; HL 07386-02/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Oleic Acids; 112-80-1/Oleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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