Document Detail

Effect of esophageal acid and prophylactic rabeprazole on performance in runners.
MedLine Citation:
PMID:  16960528     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Acid reflux occurs during exercise. The effects of esophageal acid and prophylactic antisecretory treatment on exercise performance are unknown.
AIMS: To determine 1) the effect of esophageal acid perfusion during exercise on pulmonary function and exercise performance, and 2) whether acid suppression with rabeprazole (RAB) 20 mg x d(-1) increases exercise performance during esophageal acid infusion.
METHODS: This was a two-phase study. Twenty-four conditioned runners (11 with heartburn, 13 without) completed phase 1. Sixteen runners with heartburn completed phase 2 (RAB). For phase 1, esophageal evaluation, baseline maximum exertion test, and a standard Bruce protocol maximal stress test were performed. Runners were randomized to sham esophageal infusion (NG tube placed in the distal esophagus, no fluid) or esophageal acid perfusion (0.1 N HCl perfused) during exercise. Subjects were crossed over to the alternate perfusion. For phase 2, runners underwent three sessions with both acid and sham perfusion during running; the sessions were randomly conducted on different days at baseline and 8 and 12 wk of RAB 20 mg.
RESULTS: For phase 1, esophageal function and sensitivity were normal. There was no difference in airway resistance or work capacity between groups. The acid-perfusion group significantly decreased time to exhaustion in the no-heartburn group (23.13 to 20.66 min) with a decrease in energy expenditure. For phase 2, time to exhaustion was significantly decreased with acid perfusion at all time points (P < 0.05). Total energy expenditure during exercise was less in each acid-perfusion test. No difference in pulmonary function was present at week 12 versus baseline.
CONCLUSIONS: Esophageal acid perfusion decreased performance. In runners with heartburn, suppression of endogenous acid secretion did not improve exercise performance. Changes in cardiopulmonary function do not explain the decreased exercise performance during acid perfusion.
Sheila Rodriguez-Stanley; Debra Bemben; Sattar Zubaidi; Nancy Redinger; Philip B Miner
Related Documents :
2102918 - Pulse rate, pre-competition tension and performance in 10,000 meter elite runners of bo...
9710858 - Coagulation and thrombomodulin in response to exercise of different type and duration.
8107548 - Effect of run vs combined cycle/run training on vo2max and running performance.
12165688 - Changes in spring-mass characteristics during treadmill running to exhaustion.
22073428 - Non-exercise physical activity in agricultural and urban people.
8851898 - Exercise thermoregulation after 6 h of chair rest, 6 degrees head-down bed-rest, and wa...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  38     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-12-12     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1659-65     Citation Subset:  IM; S    
Oklahoma Foundation for Digestive Research, Oklahoma City, OK 73104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
2-Pyridinylmethylsulfinylbenzimidazoles / pharmacology*
Anti-Ulcer Agents / pharmacology*
Esophagus / chemistry,  drug effects
Exercise Test / drug effects*,  methods
Gastroesophageal Reflux / drug therapy,  etiology
Heartburn / drug therapy*,  etiology
Hydrochloric Acid / adverse effects
Physical Exertion / drug effects,  physiology*
Running / physiology*
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 32828355LL/rabeprazole; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Two percent dehydration impairs and six percent carbohydrate drink improves boys basketball skills.
Next Document:  The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer.