Document Detail

Effect of erythropoietin treatment on tissue oxygenation in patients with severe transfusion dependent renal anaemia.
MedLine Citation:
PMID:  8258026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Severe renal anaemia can now be effectively treated with recombinant human erythropoietin (rhEpo). To evaluate muscle tissue oxygenation in patients with severe renal anaemia and the effects of an rhEpo treatment, muscle tissue oxygen tensions were measured in 9 patients suffering from end stage renal disease with severe renal anaemia before and during rhEpo treatment. METHODS: Muscle tissue oxygen pressure (method according to Ehrly and Schroeder), transcutaneous oxygen pressure (tcpO2) (Radiometer, Copenhagen), haematocrit (micro haematocrit method), plasma viscosity (Ostwald capillary viscometer) and erythrocyte aggregation (method according to Ehrly and Schmitt) were determined before as well as 4, 8, and 24 weeks after onset of treatment with 80 U/kg body weight 3 times per week. RESULTS: Muscle tissue pO2 values before treatment were markedly diminished when compared with normals and showed a marked increase into the normal range parallel to the increase in haematocrit. tcpO2 values were in the upper normal range before treatment and did not show significant changes during treatment. Erythrocyte aggregation and plasma viscosity did also not show significant changes. CONCLUSION: During rhEpo treatment a marked increase of muscle tissue pO2 can be found. This increase may be one of the mechanisms responsible for the improved well being and physical exercise tolerance in these patients due to erythropoietin treatment.
H Landgraf; P Grützmacher; C Garcia-Bartels; M Bergmann; A M Ehrly; W Schoeppe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of medicine     Volume:  2     ISSN:  1165-0478     ISO Abbreviation:  Eur J Med     Publication Date:    1993 Aug-Sep
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9209793     Medline TA:  Eur J Med     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  393-7     Citation Subset:  IM    
Department of Angiology, University Hospital, Frankfurt, Germany.
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MeSH Terms
Anemia / blood,  etiology*,  therapy*
Blood Transfusion*
Blood Viscosity
Erythrocyte Aggregation
Erythropoietin / therapeutic use*
Kidney Failure, Chronic / complications*,  metabolism
Middle Aged
Muscles / metabolism
Oxygen / metabolism*
Recombinant Proteins / therapeutic use
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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