| Effect of erythrocytes on the hepatic distribution kinetics of antipyrine. | |
| | |
MedLine Citation:
|
PMID: 15151169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of erythrocyte on the hepatic distribution kinetics of antipyrine was investigated in the in situ isolated perfused rat liver. Perfusion experiments were conducted using Krebs-bicarbonate buffer delivered via the portal vein in a single pass mode at a total flow rate of 15 ml/min. A bolus dose of antipyrine was administered in the presence and absence of erythrocytes. Almost identical moment analysis results (without erythrocytes mean transit time, MTT: 23 s; volume of distribution, VH: 0.57 ml/g liver and with erythrocytes, MTT: 24 s; VH: 0.60 ml/g liver) and superimposable unimodal effluent curves were obtained in the presence and absence of erythrocytes indicates that distribution kinetics of antipyrine within the liver is not affected by erythrocytes. |
| | |
Authors:
|
Selma Sahin; Malcolm Rowland |
Related Documents
:
|
7068119 - Effects of ticrynafen on hepatic excretory function in the isolated perfused rat liver. 22112129 - Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-stoke... 6858199 - Effect of perfluorodecalin on the microsomal mono-oxygenase system in perfused rat livers. 10493939 - Zonation of gluconeogenesis, ketogenesis and intracellular ph in livers from normal and... 10807679 - Reversal of the vasoconstrictor step of hyperacute xenogeneic rejection of the liver by... 3994679 - Rapid thyroid-hormone effect on mitochondrial and cytosolic atp/adp ratios in the intac... 11493279 - In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a f... 15205039 - Background concentrations of dioxins, furans, and pcbs in sprague-dawley rats and juven... 7539259 - An animal model of congenital defect of gene expression of cholecystokinin (cck)-a rece... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of drug metabolism and pharmacokinetics Volume: 29 ISSN: 0378-7966 ISO Abbreviation: Eur J Drug Metab Pharmacokinet Publication Date: 2004 Jan-Mar |
Date Detail:
|
Created Date: 2004-05-20 Completed Date: 2004-12-13 Revised Date: 2011-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 37-41 Citation Subset: IM |
Affiliation:
|
Hacettepe University, Faculty of Pharmacy, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antipyrine / pharmacokinetics* Erythrocytes / physiology* Liver / metabolism* Male Rats Rats, Sprague-Dawley Tissue Distribution / physiology |
| Chemical | |
Reg. No./Substance:
|
60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in Wistar r...
Next Document: Multiplicative dependence of the first order rate constant and its impact on clinical pharmacokineti...