| Effect of erythrocyte aggregation and flow rate on cell-free layer formation in arterioles. | |
| | |
MedLine Citation:
|
PMID: 20348228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Formation of a cell-free layer is an important dynamic feature of microcirculatory blood flow, which can be influenced by rheological parameters, such as red blood cell aggregation and flow rate. In this study, we investigate the effect of these two rheological parameters on cell-free layer characteristics in the arterioles (20-60 mum inner diameter). For the first time, we provide here the detailed temporal information of the arteriolar cell-free layer in various rheological conditions to better describe the characteristics of the layer variation. The rat cremaster muscle was used to visualize arteriolar flows, and the extent of aggregation was raised by dextran 500 infusion to levels seen in normal human blood. Our results show that cell-free layer formation in the arterioles is enhanced by a combination of flow reduction and red blood cell aggregation. A positive relation (P < 0.005) was found between mean cell-free layer widths and their corresponding SDs for all conditions. An analysis of the frequency and magnitudes of cell-free layer variation from their mean value revealed that the layer deviated with significantly larger magnitudes into the red blood cell core after flow reduction and dextran infusion (P < 0.05). In accordance, the disparity of cell-free layer width distribution found in opposite radial directions from its mean became greater with aggregation in reduced flow conditions. This study shows that the cell-free layer width in arterioles is dependent on both flow rate and red blood cell aggregability, and that the temporal variations in width are asymmetric with a greater excursion into the red blood cell core than toward the vessel wall. |
| | |
Authors:
|
Peng Kai Ong; Bumseok Namgung; Paul C Johnson; Sangho Kim |
Related Documents
:
|
9491768 - An inhibitor of aldose reductase and sorbitol accumulation from anthocepharus chinensis. 15879218 - Swimming against the flow: a mechanism of zooplankton aggregation. 3497788 - Preoperative localization of intermittently bleeding small intestinal tumors using tc-9... 3373148 - Effects of ageing on preserved red blood cell populations as measured by light scattering. 22612858 - Blood transfusion practice in a rural hospital in northern ghana, damongo, west gonja d... 3581188 - Vascular aspects and hemodynamic consequences of central nervous system injury. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-26 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 298 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-20 Completed Date: 2010-06-23 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1870-8 Citation Subset: IM |
Affiliation:
|
Division of Bioengineering and Department of Surgery, National University of Singapore, Singapore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticoagulants / pharmacology Arterioles / cytology, physiology* Dextrans / pharmacology Erythrocyte Aggregation / drug effects, physiology* Microcirculation / physiology Models, Animal Muscle, Skeletal / blood supply* Rats Rats, Inbred WF Regional Blood Flow / physiology* Rheology |
| Grant Support | |
ID/Acronym/Agency:
|
HL-52684/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 9004-54-0/Dextrans |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Integrated control of pulmonary vascular tone by endothelin and angiotensin-II in exercising swine d...
Next Document: Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway.